Technology Process of Carbamic acid, N-(6-chloro-2-formyl-3-pyridinyl)-, 1,1-dimethylethyl ester
There total 4 articles about Carbamic acid, N-(6-chloro-2-formyl-3-pyridinyl)-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (2-bromo-6-chloropyridin-3-yl)carbamate;
With
methyllithium;
In
tetrahydrofuran; formaldehyde diethyl acetal;
at -55 - -40 ℃;
for 0.75h;
Inert atmosphere;
N,N-dimethyl-formamide;
With
n-butyllithium;
In
tetrahydrofuran; formaldehyde diethyl acetal; hexane;
at 20 ℃;
under 2068.65 - 2585.81 Torr;
DOI:10.1021/op300031r
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 15 - 25 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -5 - 20 °C / Inert atmosphere
3.1: methyllithium / tetrahydrofuran; formaldehyde diethyl acetal / 0.75 h / -55 - -40 °C / Inert atmosphere
3.2: 20 °C / 2068.65 - 2585.81 Torr
With
N-Bromosuccinimide; methyllithium; sodium hexamethyldisilazane;
In
tetrahydrofuran; formaldehyde diethyl acetal; N,N-dimethyl-formamide;
DOI:10.1021/op300031r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -5 - 20 °C / Inert atmosphere
2.1: methyllithium / tetrahydrofuran; formaldehyde diethyl acetal / 0.75 h / -55 - -40 °C / Inert atmosphere
2.2: 20 °C / 2068.65 - 2585.81 Torr
With
methyllithium; sodium hexamethyldisilazane;
In
tetrahydrofuran; formaldehyde diethyl acetal;
DOI:10.1021/op300031r
