1227958-32-8

Basic information

• Product Name: tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate
• Synonyms: tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate;N-(2-Bromo-6-chloro-3-pyridinyl)carbamic acid 1,1-dimethylethyl ester
• CAS NO: 1227958-32-8
• Molecular Formula: C10H12BrClN2O2
• Molecular Weight: 308
• Mol File: 1227958-32-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 325.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.539±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.13±0.70(Predicted)
• CAS DataBase Reference: tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate(1227958-32-8)
• EPA Substance Registry System: tert-butyl 2-broMo-6-chloropyridin-3-ylcarbaMate(1227958-32-8)

Safety Data

• Hazardous Substances Data: 1227958-32-8(Hazardous Substances Data)

Usage

Description

tert-Butyl 2-bromo-6-chloropyridin-3-ylcarbamate is a chemical compound characterized by its unique molecular structure, featuring a tert-butyl group, a bromo substituent at the 2nd position, a chloro substituent at the 6th position, and a carbamate functional group attached to the pyridine ring. tert-Butyl 2-bromo-6-chloropyridin-3-ylcarbamate is known for its reactivity and potential applications in various chemical and pharmaceutical processes.

Uses

Used in Pharmaceutical Industry:
tert-Butyl 2-bromo-6-chloropyridin-3-ylcarbamate is used as a reactant in the industrial manufacture of an Akt kinase inhibitor. Akt kinase, also known as protein kinase B, plays a crucial role in cell survival, growth, and metabolism. Inhibition of Akt kinase has been shown to have potential therapeutic benefits in treating various diseases, including cancer and neurodegenerative disorders. tert-Butyl 2-bromo-6-chloropyridin-3-ylcarbamate's unique structure allows it to be a key intermediate in the synthesis of such inhibitors, contributing to the development of novel therapeutic agents.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1050501-88-6 2-bromo-6-chloro-pyridin-3-amine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 

Downstream Products

• 1199556-78-9 6-chloro-3-phenyl-1,5-naphthyridin-2(1H)-one 
• 1199556-79-0 6-hydrazinyl-3-phenyl-1,5-naphthyridin-2(1H)-one 
• 1199557-01-1 1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a][1,5]-naphthyridin-7(6H)-one 
• 1370618-02-2 1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a][1,5]-naphthyridin-7-yl trifluoromethanesulfonate 
• 1199557-02-2 7-chloro-1-(difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a]-1,5-naphthyridine 
• 1199557-04-4 tert-butyl (6-chloro-2-formylpyridin-3-yl)carbamate 

Relevant articles and documents

Convergent, kilogram scale synthesis of an Akt kinase inhibitor

The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target molecule. A key early transformation, for which