(R)-3-(Methoxymethyl)morpholine HCl

Base Information

• Chemical Name: (R)-3-(Methoxymethyl)morpholine HCl
• CAS No.: 696582-88-4
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Mol file: 696582-88-4.mol

Synonyms:(3R)-3-(methoxymethyl)morpholine,hydrochloride

Chemical Property of (R)-3-(Methoxymethyl)morpholine HCl

Chemical Property:

• Vapor Pressure: 0.929mmHg at 25°C
• Boiling Point: 179.7ºC at 760 mmHg
• Flash Point: 63.3ºC
• PSA: 30.49000
• Density: 0.954g/cm3
• LogP: -0.05000

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-(Methoxymethyl)morpholinehydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-(Methoxymethyl)morpholine HCl

There total 6 articles about (R)-3-(Methoxymethyl)morpholine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(R)-benzyl 3-(methoxymethyl)morpholine-4-carboxylate (1445591-33-2) → (R)-3-(methoxymethyl)morpholine (696582-88-4)

Guidance literature:

With palladium on carbon; In methanol; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

(R)-4-benzyl-3-(methoxymethyl)morpholine → (R)-3-(methoxymethyl)morpholine (696582-88-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.1021/acs.jmedchem.6b01245

Reference yield:

(R)-benzyl 3-(hydroxymethyl)morpholine-4-carboxylate (441717-93-7) → (R)-3-(methoxymethyl)morpholine (696582-88-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silver(l) oxide / tetrahydrofuran / 0.5 h / 20 °C

1.2: 48 h / 45 °C

2.1: palladium on carbon / methanol / 24 h / 20 °C / Inert atmosphere

With palladium on carbon; silver(l) oxide; In tetrahydrofuran; methanol;

upstream raw materials:

(R)-benzyl 3-(hydroxymethyl)morpholine-4-carboxylate

(R)-3-hydroxymethylmorpholine

(R)-benzyl 3-(methoxymethyl)morpholine-4-carboxylate

(3R)-4-benzyl-3-(hydroxymethyl)-morpholine

Refernces

• 1、 -. "NOVEL HEPATITIS C VIRUS INHIBITORS". . . Retrieved 2013/07/05.