(R)-3-Hydroxymethylmorpholine

Base Information

Chemical Name:(R)-3-Hydroxymethylmorpholine
CAS No.:211053-49-5
Molecular Formula:C5H11NO2
Molecular Weight:117.148
Hs Code.:2934999090
European Community (EC) Number:801-515-0
ChEMBL ID:CHEMBL4538536
Mol file:211053-49-5.mol

Synonyms:211053-49-5;(R)-3-Hydroxymethylmorpholine;(R)-morpholin-3-ylmethanol;3(R)-Hydroxymethylmorpholine;[(3R)-morpholin-3-yl]methanol;(3R)-Hydroxymethylmorpholine;(3R)-morpholin-3-ylmethanol;(R)-3-hydroxymethyl-morpholine;3-Morpholinemethanol, (3R)-;(R)-3-(Hydroxymethyl)morpholine;MFCD06799479;(3R)-Morpholin-3-yl-methanol;SCHEMBL18083;(3R)-Morpholine-3-methanol;(R)-Morpholin-3-yl-methanol;((R)-Morpholin-3-yl)methanol;CHEMBL4538536;AMY2068;MFCD08447310;AKOS006284529;3(R)-hydroxymethylmorpholine, AldrichCPR;DS-15088;CS-0034507;A18441

Suppliers and Price of (R)-3-Hydroxymethylmorpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3R)-Hydroxymethylmorpholine
500mg
$ 855.00

Matrix Scientific
(R)-3-Hydroxymethylmorpholine 95+%
5g
$ 4100.00

Matrix Scientific
(R)-3-Hydroxymethylmorpholine 95+%
500mg
$ 239.00

Matrix Scientific
(R)-3-Hydroxymethylmorpholine 95+%
1g
$ 475.00

Labseeker
3(R)-HYDROXYMETHYLMORPHOLINE 98
1g
$ 246.00

J&W Pharmlab
(R)-3-hydroxymethyl-morpholine 97%
5g
$ 540.00

J&W Pharmlab
(R)-3-hydroxymethyl-morpholine 97%
1g
$ 175.00

J&W Pharmlab
(R)-3-hydroxymethyl-morpholine 97%
500mg
$ 137.00

J&W Pharmlab
(R)-3-hydroxymethyl-morpholine 97%
250mg
$ 117.00

J&W Pharmlab
(R)-3-hydroxymethyl-morpholine 97%
100mg
$ 98.00

Total 50 raw suppliers

Chemical Property of (R)-3-Hydroxymethylmorpholine

Chemical Property:

Appearance/Colour:White to off-white solid
Vapor Pressure:0.0268mmHg at 25°C
Melting Point:78-81 °C
Refractive Index:1.441
Boiling Point:218.349 °C at 760 mmHg
PKA:14.85±0.10(Predicted)
Flash Point:85.855 °C
PSA：41.49000
Density:1.045 g/cm³
LogP:-0.70410
Storage Temp.:-20°C Freezer
Solubility.:Chloroform
XLogP3:-1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:117.078978594
Heavy Atom Count:8
Complexity:67.4

Purity/Quality:

98% ^*data from raw suppliers

(3R)-Hydroxymethylmorpholine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCC(N1)CO
Isomeric SMILES:C1COC[C@H](N1)CO
Uses A chiral morpholine drivative. A chiral morpholine drivative

Technology Process of (R)-3-Hydroxymethylmorpholine

There total 2 articles about (R)-3-Hydroxymethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 101376-26-5
(3R)-4-benzyl-3-(hydroxymethyl)-morpholine

: 211053-49-5
(R)-3-hydroxymethylmorpholine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 48h; under 2100.21 Torr;
DOI:10.1021/acs.jmedchem.9b00972

Reference yield:

: 106973-37-9
(3S)-5-oxo-4-(phenylmethyl)-3-morpholinecarboxylic acid

: 211053-49-5
(R)-3-hydroxymethylmorpholine

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex; triethylamine / tetrahydrofuran / 5 h / 0 - 65 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 48 h / 2100.21 Torr

With dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/acs.jmedchem.9b00972