3(R)-HYDROXYMETHYL-4-BENZYLMORPHOLINE

Base Information

• Chemical Name: 3(R)-HYDROXYMETHYL-4-BENZYLMORPHOLINE
• CAS No.: 441717-93-7
• Molecular Formula: C12H17NO2
• Molecular Weight: 251.282
• Mol file: 441717-93-7.mol

Synonyms:3(R)-HYDROXYMETHYL-4-BENZYLMORPHOLINE;Zinc04202899;(R)-4-Cbz-3-hydroxyMethylMorpholine;(3R)-3-(Hydroxymethyl)-4-morpholinecarboxylic Acid Phenylmethyl Ester

Chemical Property of 3(R)-HYDROXYMETHYL-4-BENZYLMORPHOLINE

Chemical Property:

• PSA: 59.00000
• LogP: 0.95420

Purity/Quality:

NLT 98% ^*data from raw suppliers

3(R)-HYDROXYMETHYL-4-BENZYL MORPHOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3(R)-HYDROXYMETHYL-4-BENZYLMORPHOLINE

There total 2 articles about 3(R)-HYDROXYMETHYL-4-BENZYLMORPHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[(3R)-morpholin-3-yl]methanol hydrochloride (1212377-10-0) + benzyl chloroformate (501-53-1,94274-21-2) → (R)-benzyl 3-(hydroxymethyl)morpholine-4-carboxylate (441717-93-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield: 56.0%

(R)-3-hydroxymethylmorpholine (211053-49-5) + benzyl chloroformate (501-53-1,94274-21-2) → (R)-benzyl 3-(hydroxymethyl)morpholine-4-carboxylate (441717-93-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 33.0%

(R)-benzyl 3-(hydroxymethyl)morpholine-4-carboxylate (441717-93-7) + methyl iodide (74-88-4) → (R)-benzyl 3-(methoxymethyl)morpholine-4-carboxylate (1445591-33-2)

Guidance literature:

(R)-benzyl 3-(hydroxymethyl)morpholine-4-carboxylate; With silver(l) oxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at 45 ℃; for 48h;

upstream raw materials:

[(3R)-morpholin-3-yl]methanol hydrochloride

benzyl chloroformate

(R)-3-hydroxymethylmorpholine

Downstream raw materials:

(S)-benzyl 3-(tert-butoxymethyl) morpholine-4-carboxylate

((1,2-trans)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((S)-3-(tert-butoxymethyl)morpholino)methanone

(R)-3-(methoxymethyl)morpholine

(R)-benzyl 3-(methoxymethyl)morpholine-4-carboxylate

Refernces

• 1、 -. "NOVEL HEPATITIS C VIRUS INHIBITORS". Page/Page column 46. . Retrieved 2013/07/05.