2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE

Base Information

• Chemical Name: 2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE
• CAS No.: 286441-66-5
• Molecular Formula: C10H9F3O3
• Molecular Weight: 234.17
• Hs Code.: 2916399090
• Mol file: 286441-66-5.mol

Synonyms:2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE;2-METHOXY-4-TRIFLUROMETHYL METHYLBENZOATE

Chemical Property of 2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE

Chemical Property:

• Vapor Pressure: 0.0109mmHg at 25°C
• Boiling Point: 262.5°C at 760 mmHg
• Flash Point: 109.2°C
• Density: 1.266g/cm³

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-4-trifluoromethyl-benzoicacidmethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE

There total 2 articles about 2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

sodium methylate (124-41-4) + methyl 2-fluoro-4-(trifluoromethyl)benzoate (220162-64-1) → methyl 2-methoxy-4-(trifluoromethyl)benzoate (286441-66-5)

Guidance literature:

In methanol; at 20 ℃; for 5h;

DOI:10.1248/cpb.48.694

Reference yield:

4-trifluoromethylsalicylic acid (328-90-5) + methyl iodide (74-88-4) → methyl 2-methoxy-4-(trifluoromethyl)benzoate (286441-66-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 20h;

DOI:10.1021/jm060683e

Reference yield: 99.0%

methyl 2-methoxy-4-(trifluoromethyl)benzoate (286441-66-5) → 2-methoxy-4-(trifluoromethyl)benzyl alcohol (286441-68-7)

Guidance literature:

With diisobutylaluminium hydride; In toluene;

DOI:10.1016/j.bmcl.2015.09.005

upstream raw materials:

sodium methylate

methyl 2-fluoro-4-(trifluoromethyl)benzoate

4-trifluoromethylsalicylic acid

methyl iodide

Downstream raw materials:

2-methoxy-4-(trifluoromethyl)benzyl alcohol

2-methoxy-4-(trifluoromethyl)-benzoic acid

1-<2-Hydroxy-4-(trifluoromethyl)phenyl>ethanone

2-methoxy-4-(trifluoromethyl)benzaldehyde

Refernces

• 1、 Oida, Sadao,Tajima, Yawara,Konosu, Toshiyuki,Nakamura, Yoshie,Somada, Atsushi,Tanaka, Teruo,Habuki, Shinobu,Harasaki, Tamako,Kamai, Yasuki,Fukuoka, Takashi,Ohya, Satoshi,Yasuda, Hiroshi. "Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives". . p. 694 - 707. Retrieved 2007/10/03.