Methyl (S)-4-Benzyl-3-morpholinecarboxylate

Base Information

• Chemical Name: Methyl (S)-4-Benzyl-3-morpholinecarboxylate
• CAS No.: 1235387-14-0
• Molecular Formula: C13H17NO3
• Molecular Weight: 235
• Hs Code.: 2934999090
• Mol file: 1235387-14-0.mol

Synonyms:(S)-Methyl 4-benzylmorpholine-3-carboxylate;

Chemical Property of Methyl (S)-4-Benzyl-3-morpholinecarboxylate

Chemical Property:

• PSA: 38.77000
• LogP: 0.99830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Methyl4-benzylmorpholine-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl (S)-4-Benzyl-3-morpholinecarboxylate

There total 6 articles about Methyl (S)-4-Benzyl-3-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + C12H18N2O3 → C13H17NO3 (1235387-14-0,212650-44-7)

Guidance literature:

C₁₂H₁₈N₂O₃; With sulfuric acid; In water; for 15h; Reflux;

methanol; With thionyl chloride; for 2.5h; Cooling with ice; Reflux;

Reference yield:

methanol (67-56-1) + C12H18N2O3 → C13H17NO3 (1235387-14-0,212650-44-7)

Guidance literature:

C₁₂H₁₈N₂O₃; With sulfuric acid; In water; for 11h; Reflux;

methanol; With thionyl chloride; for 4.5h; Cooling with ice; Reflux;

Reference yield:

N-Benzyl-L-serinamide → C13H17NO3 (1235387-14-0,212650-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water / 20 °C / Cooling with ice

2.1: sulfuric acid / water / 15 h / Reflux

2.2: 2.5 h / Cooling with ice; Reflux

With sulfuric acid; In water;

upstream raw materials:

methanol

benzaldehyde

Downstream raw materials:

(S)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid

(S)-4-tert-butyl 3-methyl morpholine-3,4-dicarboxylate

(R)-methyl N-tert-butoxycarbonylmorpholine-3-carboxylate

(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

Refernces