5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

Base Information

• Chemical Name: 5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
• CAS No.: 18593-44-7
• Molecular Formula: C8H8N2OS
• Molecular Weight: 180.23
• Hs Code.: 2934999090
• Mol file: 18593-44-7.mol

Synonyms:OTAVA-BB BB0127460562;TIMTEC-BB SBB009541;5,6-DIMETHYL-3 H-THIENO[2,3-D ]PYRIMIDIN-4-ONE;AKOS MSC-0512;AKOS 91440;AKOS B020883;ART-CHEM-BB B020883;

Chemical Property of 5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

Chemical Property:

• Melting Point: 269-270℃ (ethanol )
• PSA: 73.99000
• LogP: 1.60140
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dimethylthieno[2,3-d]pyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-20/21/22
• Safety Statements: 3/7-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

There total 14 articles about 5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester (4815-24-1) → 5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one (18593-44-7)

Guidance literature:

for 1.5h; Reflux;

DOI:10.3390/molecules15063932

Reference yield: 85.0%

2-amino-4,5-dimethylthiophene-3-carboxamide (51486-04-5) + formamide (77287-34-4,77287-35-5,60100-09-6) → 5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one (18593-44-7)

Guidance literature:

With acetic acid; at 130 ℃; for 0.166667h; Microwave irradiation;

DOI:10.13005/ojc/300209

Reference yield: 85.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester (4815-24-1) → 5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one (18593-44-7)

Guidance literature:

at 180 ℃; for 4h;

upstream raw materials:

3-amino-5,6-dimethylthieno<2,3-d>pyrimidin-4(3H)-one

formamide

2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester

3-carbethoxy-2-ethoxymethyleneimino-4,5-dimethylthiophene

Downstream raw materials:

4-chloro-5,6-dimethyl-thieno[2,3-d]pyrimidine

4-amino-5,6-dimethylthieno[2,3-d]pyrimidine

2-((5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio)acetic acid

N-cyclopropyl-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine

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