4-Bromo-2-methoxypyrimidine

Base Information

• Chemical Name: 4-Bromo-2-methoxypyrimidine
• CAS No.: 959240-72-3
• Molecular Formula: C5H5BrN2O
• Molecular Weight: 189.011
• Hs Code.: 2933599090
• Mol file: 959240-72-3.mol

Synonyms:4-Bromo-2-methoxy-1,3-diazine

Chemical Property of 4-Bromo-2-methoxypyrimidine

Chemical Property:

• Vapor Pressure: 0.0205mmHg at 25°C
• Boiling Point: 259.8ºC at 760 mmHg
• PKA: -0.42±0.20(Predicted)
• Flash Point: 110.9ºC
• PSA: 35.01000
• Density: 1.628g/cm3
• LogP: 1.24770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-methoxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2-methoxypyrimidine is a useful reactant for organic reactions and synthesis.

Technology Process of 4-Bromo-2-methoxypyrimidine

There total 2 articles about 4-Bromo-2-methoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-amino-2-methoxypyrimidine (3289-47-2) → 4-bromo-2-methoxypyrimidine (959240-72-3)

Guidance literature:

With copper(ll) bromide; isopentyl nitrite; In acetonitrile; at 82 ℃; for 6h; chemoselective reaction;

DOI:10.2174/157017811797249371

Reference yield: 17.0%

2-methoxypyrimidine (931-63-5) → 4-bromo-2-methoxypyrimidine (959240-72-3)

Guidance literature:

2-methoxypyrimidine; With 2,2,6,6-tetramethyl-piperidine; isopropyl chloride; magnesium; lithium chloride; In tetrahydrofuran; at -60 ℃; for 1h;

With bromine; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 94.0%

4-bromo-2-methoxypyrimidine (959240-72-3) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 4-(2-methoxypyrimidin-4-yl)benzoate (281233-16-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 95 ℃; Inert atmosphere;

upstream raw materials:

4-amino-2-methoxypyrimidine

2-methoxypyrimidine

Downstream raw materials:

4-(3-iodo-1H-pyrazol-1-yl)-2-methoxypyrimidine

methyl 4-(2-methoxypyrimidin-4-yl)benzoate