4-Pyrimidinecarboxamide, 1,6-dihydro-6-oxo- (6CI)

Base Information

• Chemical Name: 4-Pyrimidinecarboxamide, 1,6-dihydro-6-oxo- (6CI)
• CAS No.: 98024-63-6
• Molecular Formula: C5H5N3O2
• Molecular Weight: 139.11200
• Hs Code.: 2933599090
• Mol file: 98024-63-6.mol

Synonyms:6-Oxo-1,6-dihydro-pyrimidin-4-carbonsaeure-amid;4-pyrimidinecarboxamide,1,6-dihydro-6-oxo;6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid amide;6-hydroxypyrimidine-4-carboxamide;

Chemical Property of 4-Pyrimidinecarboxamide, 1,6-dihydro-6-oxo- (6CI)

Chemical Property:

• PSA: 90.09000
• LogP: 0.16530
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Hydroxypyrimidine-4-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidinecarboxamide, 1,6-dihydro-6-oxo- (6CI)

There total 3 articles about 4-Pyrimidinecarboxamide, 1,6-dihydro-6-oxo- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

acetamidine hydrochloride (124-42-5) + acetylenedicarboxylic acid diethyl ester (762-21-0) → 6-oxo-1H-pyrimidine-4-carboxamide (98024-63-6)

Guidance literature:

acetamidine hydrochloride; acetylenedicarboxylic acid diethyl ester; With triethylamine; In acetonitrile; for 72h; Reflux;

With ammonia; In methanol; at 20 ℃; Reflux;

Reference yield:

ethyl 6-hydroxypyrimidine-4-carboxylate → 6-hydroxy-4-pyrimidinecarboxamide (98024-63-6)

Guidance literature:

With ammonia; at 0 - 20 ℃;

Reference yield:

methyl 6-oxo-1,6-dihydropyrimidine-4-carboxylate (7399-93-1) → 6-oxo-1H-pyrimidine-4-carboxamide (98024-63-6)

Guidance literature:

With ammonia; water;

upstream raw materials:

methyl 6-oxo-1,6-dihydropyrimidine-4-carboxylate

acetamidine hydrochloride

acetylenedicarboxylic acid diethyl ester

Downstream raw materials:

6-chloropyrimindine-4-carbonitrile