4-Pyrimidinecarboxylicacid,1,6-dihydro-6-oxo-,ethylester(9CI)

Base Information

• Chemical Name: 4-Pyrimidinecarboxylicacid,1,6-dihydro-6-oxo-,ethylester(9CI)
• CAS No.: 223788-14-5
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Hs Code.: 2933599090
• Mol file: 223788-14-5.mol

Synonyms:4-Pyrimidinecarboxylicacid,1,6-dihydro-6-oxo-,ethylester(9CI);4-PYRIMIDINECARBOXYLIC ACID, 1,6-DIHYDRO-6-OXO-, ETHYL ESTER;ethyl 6-hydroxypyrimidine-4-carboxylate

Chemical Property of 4-Pyrimidinecarboxylicacid,1,6-dihydro-6-oxo-,ethylester(9CI)

Chemical Property:

• Refractive Index: 1.567
• Boiling Point: 276.7±50.0 °C(Predicted)
• PKA: 6.99±0.40(Predicted)
• PSA: 72.05000
• Density: 1.33g/cm³
• LogP: -0.05340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl6-oxo-3,6-dihydropyrimidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidinecarboxylicacid,1,6-dihydro-6-oxo-,ethylester(9CI)

There total 1 articles about 4-Pyrimidinecarboxylicacid,1,6-dihydro-6-oxo-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

formamidine hydrochloride (6313-33-3) + acetylenedicarboxylic acid diethyl ester (762-21-0) → ethyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate (223788-14-5)

Guidance literature:

With triethylamine; In acetonitrile; for 4h; Reflux;

Reference yield:

ethyl 6-oxo-3,6-dihydropyrimidine-4-carboxylate (223788-14-5) → 6-chloropyrimindine-4-carbonitrile (939986-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / 18 h / 0 - 20 °C

2: trichlorophosphate / 18 h / Reflux

With ammonium hydroxide; trichlorophosphate;

upstream raw materials:

formamidine hydrochloride

acetylenedicarboxylic acid diethyl ester

Downstream raw materials:

6-chloropyrimindine-4-carbonitrile

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