(R,R,R)-2-Azabicyclo[3.3.0]octane-3-carboxylic Acid Benzyl Ester Hydrochloride Salt

Base Information

• Chemical Name: (R,R,R)-2-Azabicyclo[3.3.0]octane-3-carboxylic Acid Benzyl Ester Hydrochloride Salt
• CAS No.: 138877-09-5
• Molecular Formula: C₁₅H₁₉NO₂*ClH
• Molecular Weight: 281.782
• Mol file: 138877-09-5.mol

Synonyms:[2R-(2α,3aβ,6aβ)]-Octahydro-cyclopenta[b]pyrrole-2-carboxylic Acid PhenylMethyl Ester Hydrochloride

Chemical Property of (R,R,R)-2-Azabicyclo[3.3.0]octane-3-carboxylic Acid Benzyl Ester Hydrochloride Salt

Chemical Property:

• Melting Point: 197-199 C
• Storage Temp.: Refrigerator

Purity/Quality:

99% ^*data from raw suppliers

(R,R,R)-2-Azabicyclo[3.3.0]octane-3-carboxylicAcidBenzylEsterHydrochlorideSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R,R,R)-2-Azabicyclo[3.3.0]octane-3-carboxylic Acid Benzyl Ester Hydrochloride Salt

There total 33 articles about (R,R,R)-2-Azabicyclo[3.3.0]octane-3-carboxylic Acid Benzyl Ester Hydrochloride Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

S,S,S-2-azabicyclo[3,3,0]-octane-3-carboxylic acid benzyl ester L-mandelic acid salt (135214-79-8) → benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride (87269-87-2,87679-25-2,88547-79-9,93779-29-4,94569-19-4,138877-09-5)

Guidance literature:

S,S,S-2-azabicyclo[3,3,0]-octane-3-carboxylic acid benzyl ester L-mandelic acid salt; With sodium hydroxide; In dichloromethane; water; at 25 - 30 ℃;

With hydrogenchloride; In water; isopropyl alcohol;

Reference yield: 80.0%

2-aza-bicyclo[3.3.0]octane-3-carboxylic acid (1296306-77-8,411232-21-8,726691-28-7) + benzyl alcohol (100-51-6,185532-71-2) → 2-aza-bicyclo[3.3.0]octane-3-carboxylic acid benzyl ester hydrochloride (94569-19-4) + benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride (87269-87-2,87679-25-2,88547-79-9,93779-29-4,94569-19-4,138877-09-5)

Guidance literature:

With thionyl chloride; at 0 - 25 ℃; for 13h; Inert atmosphere;

DOI:10.1080/00397911003798757

Reference yield: 70.0%

(2S,3aS,6aS)-1-(tert-butoxycarbonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid (109428-53-7,411232-21-8,726691-28-7) + benzyl alcohol (100-51-6,185532-71-2) → benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride (87269-87-2,87679-25-2,88547-79-9,93779-29-4,94569-19-4,138877-09-5)

Guidance literature:

With hydrogenchloride; thionyl chloride; In 1,4-dioxane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/cmdc.202000017

upstream raw materials:

(1RS,3RS,5RS)-2-Azabicyclo<3.3.0>octan-3-carbonsaeurebenzylester-hydrochlorid

(S)-2-Benzyloxycarbonylamino-3-phenyl-propionic acid; compound with (2S,3aS,6aS)-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester

benzyl (1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylate

benzyl alcohol

Downstream raw materials:

benzyl (1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylate

2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester

(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

(S,S,S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid hydrochloride

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