2-Amino-3-methylamino-5-phenylpyridine

Base Information

• Chemical Name: 2-Amino-3-methylamino-5-phenylpyridine
• CAS No.: 107351-81-5
• Molecular Formula: C12H13N3
• Molecular Weight: 199.255
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90399551
• Nikkaji Number: J903.405F
• Wikidata: Q82202185
• Mol file: 107351-81-5.mol

Synonyms:2-AMINO-3-METHYLAMINO-5-PHENYLPYRIDINE;107351-81-5;3-N-methyl-5-phenylpyridine-2,3-diamine;N3-Methyl-5-phenylpyridine-2,3-diamine;starbld0018827;SCHEMBL1744852;DTXSID90399551;AKOS006280057;N'-Methyl-5-phenylpyridine-2,3-diamine;FT-0661888;FT-0662091;J-001890;221163-47-9

Chemical Property of 2-Amino-3-methylamino-5-phenylpyridine

Chemical Property:

• Melting Point: 144-144.5°C
• PSA: 50.94000
• LogP: 3.02670
• Storage Temp.: Refrigerator
• Solubility.: Acetone, Chloroform, DMF, DMSO, Methanol
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 199.110947427
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-methylamino-5-phenylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=C(N=CC(=C1)C2=CC=CC=C2)N

Technology Process of 2-Amino-3-methylamino-5-phenylpyridine

There total 7 articles about 2-Amino-3-methylamino-5-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-(2-Amino-5-iodo-pyridin-3-yl)-4,N-dimethyl-benzenesulfonamide (199442-70-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-amino-3-methylamino-5-phenylpyridine (107351-81-5)

Guidance literature:

In trifluoroacetic acid; for 2h; Irradiation;

DOI:10.1016/S0040-4039(97)10039-9

Reference yield:

2-amino-3-bromo-5-phenylpyridine (107351-80-4) + methylamine (74-89-5) → 2-amino-3-methylamino-5-phenylpyridine (107351-81-5)

Guidance literature:

With copper(II) sulfate; In water; at 200 ℃; for 72h; Heating;

Reference yield:

2,3-Diaminopyridine (452-58-4) → 2-amino-3-methylamino-5-phenylpyridine (107351-81-5)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / Heating

2: K₂CO₃ / acetone / Ambient temperature

3: 68 percent / I₂ / H₂O; acetic acid / 80 °C

4: 45 percent / trifluoroacetic acid / 2 h / Irradiation

With iodine; potassium carbonate; In pyridine; water; acetic acid; acetone; trifluoroacetic acid;

DOI:10.1016/S0040-4039(97)10039-9

upstream raw materials:

2-amino-3-bromo-5-phenylpyridine

methylamine

N-(2-Amino-5-iodo-pyridin-3-yl)-4,N-dimethyl-benzenesulfonamide

benzene

Downstream raw materials:

1-methyl-6-phenyl-2-N-(p-toluenesulfonyl)aminoimidazo[4,5-b]pyridine

2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine

Refernces

• 1、 Bavetta, Fabio S.,Caronna, Tullio,Pregnolato, Massimo,Terreni, Marco. "An easy photochemical approach to the synthesis of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine". . p. 7793 - 7796. Retrieved 2007/10/03.