Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester

Base Information

• Chemical Name: Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester
• CAS No.: 74273-47-5
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• Mol file: 74273-47-5.mol

Synonyms:4-Methoxyphenyl-aminoessigsaeure-methylester;BB-0808;methyl p-methoxyphenylglycinate;methylaminomethoxyphenylacetatehydrochloride;F2147-0640;

Chemical Property of Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester

Chemical Property:

• Melting Point: 183～186℃
• PSA: 61.55000
• LogP: 2.37030

Purity/Quality:

98%min ^*data from raw suppliers

methyl2-amino-2-(4-methoxyphenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester

There total 13 articles about Benzeneacetic acid, a-aMino-4-Methoxy-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

di-tert-butyl 1-(2-methoxy-1-(4-methoxyphenyl)-2-oxoethyl)hydrazine-1,2-dicarboxylate → methyl 2-amino-2-(4-methoxyphenyl)acetate (74273-47-5)

Guidance literature:

di-tert-butyl 1-(2-methoxy-1-(4-methoxyphenyl)-2-oxoethyl)hydrazine-1,2-dicarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

With hydrogen; acetic acid; In ethanol; for 3.5h;

DOI:10.1021/acs.orglett.9b02769

Reference yield:

C10H11NO4 → methyl 2-amino-2-(4-methoxyphenyl)acetate (74273-47-5)

Guidance literature:

With formic acid; zinc; In methanol; water; at 0 - 20 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tet.2016.07.046

Reference yield:

amino(3-chloro-4-methoxyphenyl)acetic acid methyl ester hydrochloride (13226-99-8) → methyl 2-amino-2-(4-methoxyphenyl)acetate (74273-47-5)

Guidance literature:

With potassium hydrogencarbonate; In water;

DOI:10.1016/j.molcata.2016.06.026

upstream raw materials:

methanol

p-methoxybenzylnitrile

2-(4-methoxyphenyl)glycine

4-methoxyphenylglyoxylate methyl ester

Downstream raw materials:

N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]octanamide

2-amino-2-(4-methoxyphenyl)acetamide

2,4-bis(4-methoxyphenyl)oxazol-5(4H)-one

methyl 4-benzoyl-2-(4-methoxyphenyl)-5-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-2-carboxylate

Refernces

• 1、 Morisawa, Takuto,Sawamura, Masaya,Shimizu, Yohei. "Boron-Catalyzed α-Amination of Carboxylic Acids". . p. 7466 - 7469. Retrieved 2019/10/02.
• 2、 Ruiz, Sara,Sayago, Francisco J.,Cativiela, Carlos,Urriolabeitia, Esteban P.. "Ru-catalyzed C[sbnd]H functionalization of phenylglycine derivatives: Synthesis of isoquinoline-1-carboxylates and isoindoline-1-carboxylates". . p. 407 - 418. Retrieved 2016/12/16.