2-Amino-2-(4-methoxyphenyl)acetic acid

Base Information

• Chemical Name: 2-Amino-2-(4-methoxyphenyl)acetic acid
• CAS No.: 2540-53-6
• Molecular Formula: C9H11NO3
• Molecular Weight: 181.191
• NSC Number: 154924,101476
• Nikkaji Number: J1.009.942K
• ChEMBL ID: CHEMBL134005
• Mol file: 2540-53-6.mol

Synonyms:2-amino-2-(4-methoxyphenyl)acetic acid;19789-59-4;amino(4-methoxyphenyl)acetic acid;2540-53-6;2-Amino-2-(4-methoxyphenyl)aceticAcid;n-(4-Methoxyphenyl)-glycine;MFCD00049329;AMINO-4-METHOXYBEN-ZENEACETIC ACID;alpha-Aminohomoanisic acid;NSC 101476;NSC 154924;NSC154924;-Aminohomoanisic acid;( inverted exclamation markA)-4-Methoxyphenyl glycine;|A-Aminohomoanisic acid;Benzeneacetic acid, alpha-amino-4-methoxy-;CHEMBL134005;SCHEMBL5281443;AMY9093;GXUAKXUIILGDKW-UHFFFAOYSA-N;HMS1787F01;BBL022157;NSC101476;STK131290;AKOS000182859;AKOS016053343;Amino-(4-methoxy-phenyl)-acetic acid;6L-303S;AB32874;AB32877;NSC-101476;NSC-154924;PB10070;Benzeneacetic acid, a-amino-4-methoxy-;AC-23606;SY014170;BB 0249635;CS-0030788;FT-0637909;EN300-69643;Z56755722;F2167-0082

Chemical Property of 2-Amino-2-(4-methoxyphenyl)acetic acid

Chemical Property:

• Melting Point: 200oC (dec)
• Boiling Point: 339.5oC at 760 mmHg
• Flash Point: 159.1oC
• PSA: 72.55000
• Density: 1.246 g/cm3
• LogP: 1.47990
• XLogP3: -1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 181.07389321
• Heavy Atom Count: 13
• Complexity: 176

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C(=O)O)N

Technology Process of 2-Amino-2-(4-methoxyphenyl)acetic acid

There total 29 articles about 2-Amino-2-(4-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

p-methoxybenzoylformic acid (7099-91-4) → 2-(4-methoxyphenyl)glycine (2540-53-6,19789-59-4)

Guidance literature:

With C₂₆H₃₄ClIrN₄O; ammonium formate; In methanol; at 80 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.9b01565

Reference yield: 94.0%

benzylamino-(4-methoxy-phenyl)-acetic acid (271583-25-6) → 2-(4-methoxyphenyl)glycine (2540-53-6,19789-59-4)

Guidance literature:

With sodium hydroxide; hydrazine hydrate; palladium on activated charcoal; In water; for 10h; Heating;

DOI:10.1080/00397910008087127

Reference yield: 86.0%

5-(4-methoxyphenyl)imidazolidone-2,4-dione (6617-78-3) → 2-(4-methoxyphenyl)glycine (2540-53-6,19789-59-4)

Guidance literature:

With sodium hydroxide; for 24h; Heating;

DOI:10.1016/0223-5234(96)88263-8

upstream raw materials:

2-amino-2-(4-methoxyphenyl)acetonitrile

methyl 2-amino-2-(4-methoxyphenyl)acetate

α-Isocyano-p-anisylessigsaeureaethylester

ethyl 2-amino-2-(4-methoxyphenyl) acetate

Downstream raw materials:

4-methoxy-benzaldehyde

p-hydroxyphenylglycine

isopropyl 2-(4-methoxyphenyl)glycinate

4-(4-methoxy-phenyl)-2-trifluoromethyl-4H-oxazol-5-one