7-Azaspiro[3.5]nonane

Base Information

• Chemical Name: 7-Azaspiro[3.5]nonane
• CAS No.: 766-34-7
• Molecular Formula: C8H15N
• Molecular Weight: 125.214
• Hs Code.: 2933990090
• European Community (EC) Number: 815-373-2
• DSSTox Substance ID: DTXSID80604540
• Wikidata: Q82502527
• Mol file: 766-34-7.mol

Synonyms:7-azaspiro(3.5)nonane

Chemical Property of 7-Azaspiro[3.5]nonane

Chemical Property:

• PSA: 12.03000
• LogP: 1.86890
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 125.120449483
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

97% ^*data from raw suppliers

7-Azaspiro[3.5]nonane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2(C1)CCNCC2

Technology Process of 7-Azaspiro[3.5]nonane

There total 4 articles about 7-Azaspiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2) → 7-azaspiro[3.5]nonane (766-34-7)

Guidance literature:

With hydrazine hydrate; sodium hydroxide; at 200 ℃; for 4h; Reflux;

Reference yield:

tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) → 7-azaspiro[3.5]nonane (766-34-7)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc-copper / diethyl ether; 1,2-dimethoxyethane / 18 h / 20 °C

2: ammonium chloride; zinc / methanol / 4 h / Reflux

3: sodium hydroxide; hydrazine hydrate / 4 h / 200 °C / Reflux

With ammonium chloride; hydrazine hydrate; sodium hydroxide; zinc; In methanol; 1,2-dimethoxyethane; diethyl ether;

Reference yield:

tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (396653-31-9) → 7-azaspiro[3.5]nonane (766-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium chloride; zinc / methanol / 4 h / Reflux

2: sodium hydroxide; hydrazine hydrate / 4 h / 200 °C / Reflux

With ammonium chloride; hydrazine hydrate; sodium hydroxide; zinc; In methanol;

upstream raw materials:

tert-butyl 4-methylidenepiperidine-1-carboxylate

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

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