7-Azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dichloro-2-oxo-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 7-Azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dichloro-2-oxo-, 1,1-dimethylethyl ester
• CAS No.: 396653-31-9
• Molecular Formula: C₁₃H₁₉Cl₂NO₃
• Molecular Weight: 308.205
• Mol file: 396653-31-9.mol

Synonyms:1,1-Dichloro-2-oxo-7-aza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester;

Chemical Property of 7-Azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dichloro-2-oxo-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 46.61000
• LogP: 3.08830

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dichloro-2-oxo-, 1,1-dimethylethyl ester

There total 2 articles about 7-Azaspiro[3.5]nonane-7-carboxylic acid, 1,1-dichloro-2-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) + trifluoroacetyl chloride (76-02-8) → tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (396653-31-9)

Guidance literature:

With zinc-copper couple; In 1,2-dimethoxyethane; at 34 - 44 ℃; Inert atmosphere;

Reference yield:

sodium hydrogencarbonate (144-55-8) + tert-butyl 4-methylidenepiperidine-1-carboxylate (159635-49-1) + trifluoroacetyl chloride (76-02-8) → tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (396653-31-9)

Guidance literature:

In 1,2-dimethoxyethane; diethyl ether;

Reference yield: 97.0%

tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (396653-31-9) → tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate (203661-69-2)

Guidance literature:

With ammonium chloride; zinc; In methanol; at 20 ℃; for 10h;

DOI:10.1021/jm4014828

upstream raw materials:

tert-butyl 4-methylidenepiperidine-1-carboxylate

trifluoroacetyl chloride

sodium hydrogencarbonate

Downstream raw materials:

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

7-azaspiro[3.5]nonane-2-carbonitrile

(7-benzyl-7-azaspiro[3.5]non-2-yl)carbonitrile

2-cyano-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester