2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

• Chemical Name: 2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
• CAS No.: 880361-83-1
• Molecular Formula: C8H11N3O
• Molecular Weight: 165.19244
• Hs Code.: 2933990090
• Mol file: 880361-83-1.mol

Synonyms:2-methoxy-5H,6H,7H,8H-pyrido[4,3-d]pyrimidine;2-methoxy-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidine;

Chemical Property of 2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Chemical Property:

• Boiling Point: 327.8±34.0 °C(Predicted)
• PKA: 7.03±0.20(Predicted)
• PSA: 47.04000
• Density: 1.157±0.06 g/cm3(Predicted)
• LogP: 0.45970

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 2 articles about 2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate (900156-22-1) → 2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (880361-83-1)

Guidance literature:

tert-butyl 2-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate; With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 0.5h;

With sodium carbonate; In dichloromethane; water;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (880361-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 12 h / 120 °C / Inert atmosphere

1.2: 6 h / 70 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

2-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (880361-83-1) + 4-methoxybenzene-1-sulfonyl fluoride (368-91-2) → C15H17N3O4S

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; calcium(II) bis(trifluoromethanesulfonyl)imide; In tetrahydrofuran; at 20 ℃; for 18h; Sealed tube;

DOI:10.1021/acs.orglett.0c01397

upstream raw materials:

tert-butyl 2-methoxy-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

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