N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-methionine

Base Information

• Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-methionine
• CAS No.: 18830-16-5
• Molecular Formula: C19H28 N2 O5 S
• Molecular Weight: 396.508
• European Community (EC) Number: 242-612-2
• Nikkaji Number: J222.322H
• Mol file: 18830-16-5.mol

Synonyms:18830-16-5;Z-LEU-MET-OH;N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-methionine;EINECS 242-612-2;N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)-L-methionine;L-Methionine, N-[(phenylmethoxy)carbonyl]-L-leucyl- (9CI);N-cbz-l-leucyl-l-methionine;MFCD00026490;NSC 333760;(2S)-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-4-methylsulfanylbutanoic acid

Chemical Property of N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-methionine

Chemical Property:

• Vapor Pressure: 9.79E-18mmHg at 25°C
• Boiling Point: 649.1°Cat760mmHg
• Flash Point: 346.4°C
• PSA: 130.03000
• Density: 1.195g/cm³
• LogP: 3.43180
• Storage Temp.: -15°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 12
• Exact Mass: 396.17189317
• Heavy Atom Count: 27
• Complexity: 481

Purity/Quality:

99% ^*data from raw suppliers

Z-Leu-Met-OH 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)O)NC(=O)OCC1=CC=CC=C1
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)OCC1=CC=CC=C1

Technology Process of N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-methionine

There total 3 articles about N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Leu-OH (2018-66-8) → Z-Leu-Met-OH (18830-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: triethylamine / water; acetonitrile / Inert atmosphere

With thionyl chloride; triethylamine; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/jo1015757

Reference yield:

N-Cbz-L-Leu-Bt + L-methionine (63-68-3,26062-47-5,58576-49-1) → Z-Leu-Met-OH (18830-16-5)

Guidance literature:

With triethylamine; In water; acetonitrile; Inert atmosphere;

DOI:10.1021/jo1015757

Reference yield:

→ Z-Leu-Met-OH (18830-16-5)

Guidance literature:

Z-Leu, Met, ClCO2Et, NEt3;

DOI:10.1002/hlca.19680510102

upstream raw materials:

L-methionine

Z-Leu-OH

Downstream raw materials:

N-Cbz-Leu-Met-Bt

Z-L-Leu-L-Met-L-Cys-OH

Z-Leu-Met-Leu-NH₂