N-Ethyl-1-[(1,3-benzodioxole-5-yl)methyl]ethanamine

Base Information

• Chemical Name: N-Ethyl-1-[(1,3-benzodioxole-5-yl)methyl]ethanamine
• CAS No.: 14089-52-2
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 14089-52-2.mol

Synonyms:3H-1,2-benzodioxole-6-ethanamine, N-ethyl-alpha-methyl-; MDE; MDEA; N-Ethyl-3,4-methylenedioxyamphetamine;

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Chemical Property of N-Ethyl-1-[(1,3-benzodioxole-5-yl)methyl]ethanamine

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Boiling Point: 284.578°C at 760 mmHg
• Flash Point: 116.566°C
• PSA: 30.49000
• Density: 1.079g/cm3
• LogP: 2.34670

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Ethyl-1-[(1,3-benzodioxole-5-yl)methyl]ethanamine

There total 6 articles about N-Ethyl-1-[(1,3-benzodioxole-5-yl)methyl]ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) + ethylamine (75-04-7,85404-22-4) → 3,4-methylenedioxyethylamphetamine (14089-52-2,82801-81-8,114612-26-9,114612-27-0)

Guidance literature:

With sodium cyanoborohydride;

Reference yield:

3,4-methylenedioxyamphetamine (4764-17-4) → 3,4-methylenedioxyethylamphetamine (14089-52-2,82801-81-8,114612-26-9,114612-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / pyridine / 18 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/jps.2600690220

Reference yield:

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) → 3,4-methylenedioxyethylamphetamine (14089-52-2,82801-81-8,114612-26-9,114612-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₃CN / methanol / 36 h / Ambient temperature; neutral pH

2: 58 percent / pyridine / 18 h / Ambient temperature

3: LiAlH₄ / tetrahydrofuran / 72 h / Heating

With pyridine; lithium aluminium tetrahydride; sodium cyanoborohydride; In tetrahydrofuran; methanol;

DOI:10.1002/jps.2600690220

upstream raw materials:

1-(1,3-benzodioxol-5-yl)-2-propanone

ethanamine hydrochloride

ethylamine

N-[1-methyl-2-(3,4-methylenedioxyphenyl)ethyl]acetamide

Downstream raw materials:

3,4-methylenedioxyamphetamine