ETHYL 2-FLUOROBENZOYLFORMATE

Base Information

• Chemical Name: ETHYL 2-FLUOROBENZOYLFORMATE
• CAS No.: 1813-93-0
• Molecular Formula: C10H9FO3
• Molecular Weight: 196.178
• Hs Code.: 2918300090
• Mol file: 1813-93-0.mol

Synonyms:ETHYL 2-FLUOROBENZOYLFORMATE;ethyl 2-(2-fluorophenyl)-2-oxoacetate

Chemical Property of ETHYL 2-FLUOROBENZOYLFORMATE

Chemical Property:

• Vapor Pressure: 0.00654mmHg at 25°C
• Boiling Point: 271.2°C at 760 mmHg
• Flash Point: 114.3°C
• PSA: 43.37000
• Density: 1.213g/cm³
• LogP: 1.57150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl2-Fluorobenzoylformate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-FLUOROBENZOYLFORMATE

There total 7 articles about ETHYL 2-FLUOROBENZOYLFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl 2-diazo-3-(2-fluorophenyl)-3-oxopropanoate (1240912-19-9) → ethyl 2-(2-fluorophenyl)-2-oxoacetate (1813-93-0)

Guidance literature:

With copper(l) iodide; oxygen; In N,N-dimethyl-formamide; at 90 ℃; for 2h; Schlenk technique;

DOI:10.1021/acs.joc.0c01744

Reference yield: 55.0%

o-fluorobromobenzene (1072-85-1) + n-butyllithium (109-72-8,29786-93-4) + ethyl acetate n-hexane + imidazol-1-yl-oxo-acetic acid ethyl ester (75716-82-4) → ethyl 2-(2-fluorophenyl)-2-oxoacetate (1813-93-0)

Guidance literature:

In diethyl ether; hexane; water; sodium;

Reference yield: 50.0%

o-fluorobromobenzene (1072-85-1) + oxalic acid diethyl ester (95-92-1) → ethyl 2-(2-fluorophenyl)-2-oxoacetate (1813-93-0)

Guidance literature:

o-fluorobromobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; Inert atmosphere;

oxalic acid diethyl ester; In tetrahydrofuran; hexane; at -70 - 20 ℃;

upstream raw materials:

ethanol

2-fluoromandelic acid

2-Fluorobenzaldehyde

o-fluorobromobenzene

Downstream raw materials:

3-(2-fluorophenyl)-3-hydroxy-5-(trifluoromethyl)-1,3-dihydro-2H-indol-2-one

ethyl α,α-difluoro-α-(o-fluorophenyl)acetate

2,2-difluoro-2-(2-fluoro-phenyl)-ethanol

1-(2-azido-1,1-difluoroethyl)-2-fluorobenzene

Refernces

• 1、 Tian, Duanshuai,Li, Chengxi,Gu, Guoxian,Peng, Henian,Zhang, Xumu,Tang, Wenjun. "Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group". supporting information. p. 7176 - 7180. Retrieved 2018/05/29.
• 2、 Shirai, Tomohiko,Ito, Hajime,Yamamoto, Yasunori. "Cationic Ir/Me-BIPAM-catalyzed asymmetric intramolecular direct hydroarylation of α-ketoamides". supporting information. p. 2658 - 2661. Retrieved 2014/03/21.