Technology Process of 2-Bromo-6-methoxy-4-aminopyridine
There total 4 articles about 2-Bromo-6-methoxy-4-aminopyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-6-methoxyisonicotinamide;
With
sodium hypochlorite; sodium hydroxide;
In
water;
at 10 - 20 ℃;
for 2h;
With
sodium hydroxide;
In
water;
at 77 - 80 ℃;
for 2.33333h;
DOI:10.1021/acs.oprd.6b00392
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphorus(V) oxybromide / sulfolane / 2.82 h / 90 - 125 °C / Large scale
1.2: 1 h / 40 - 45 °C / Large scale
2.1: sodium methylate / 2-methyltetrahydrofuran / 1 h / 60 °C / Large scale
3.1: ammonium hydroxide / water / 48 h / 20 °C
4.1: sodium hypochlorite; sodium hydroxide / water / 2 h / 10 - 20 °C
4.2: 2.33 h / 77 - 80 °C
With
ammonium hydroxide; sodium hypochlorite; sodium methylate; sodium hydroxide; phosphorus(V) oxybromide;
In
2-methyltetrahydrofuran; sulfolane; water;
4.1: |Hofmann Rearrangement / 4.2: |Hofmann Elimination;
DOI:10.1021/acs.oprd.6b00392
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium methylate / 2-methyltetrahydrofuran / 1 h / 60 °C / Large scale
2.1: ammonium hydroxide / water / 48 h / 20 °C
3.1: sodium hypochlorite; sodium hydroxide / water / 2 h / 10 - 20 °C
3.2: 2.33 h / 77 - 80 °C
With
ammonium hydroxide; sodium hypochlorite; sodium methylate; sodium hydroxide;
In
2-methyltetrahydrofuran; water;
3.1: |Hofmann Rearrangement / 3.2: |Hofmann Elimination;
DOI:10.1021/acs.oprd.6b00392
