Methyl 2,6-dibromopyridine-4-carboxylate

Base Information

• Chemical Name: Methyl 2,6-dibromopyridine-4-carboxylate
• CAS No.: 119308-57-5
• Molecular Formula: C7H5 Br2 N O2
• Molecular Weight: 294.93
• Hs Code.: 2933399090
• Mol file: 119308-57-5.mol

Synonyms:Methyl2,6-Dibromo-4-pyridinecarboxylate; Methyl 2,6-dibromoisonicotinate

Chemical Property of Methyl 2,6-dibromopyridine-4-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 86.8-88.2 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.588
• Boiling Point: 320.9°Cat760mmHg
• PKA: -5.78±0.10(Predicted)
• Flash Point: 147.9°C
• PSA: 39.19000
• Density: 1.928g/cm³
• LogP: 2.39320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2,6-dibromopyridine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2,6-dibromopyridine-4-carboxylate

There total 4 articles about Methyl 2,6-dibromopyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 2,6-dibromoisonicotinic acid (2016-99-1) → methyl 2,6-dibromoisonicotinate (119308-57-5)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield: 79.0%

methanol (67-56-1) + citrazinic acid (99-11-6) → methyl 2,6-dibromoisonicotinate (119308-57-5)

Guidance literature:

citrazinic acid; With phosphorus(V) oxybromide; at 130 ℃;

methanol; at 0 ℃;

DOI:10.1021/jm100076w

Reference yield:

citrazinic acid (99-11-6) → methyl 2,6-dibromoisonicotinate (119308-57-5)

Guidance literature:

With P₂O₅; bromine; phosphorus tribromide; sodium hydrogencarbonate; In methanol; water; ethyl acetate;

upstream raw materials:

methanol

2,6-dibromoisonicotinic acid

citrazinic acid

Downstream raw materials:

2 bromo-6-methoxy-pyridin-4-ylamine

(2'-cyclohexylamino-6-piperazin-1-yl-[2,4']bipyridinyl-4-yl)-methanol

(4-aminomethyl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-cyclohexyl-amine

2'-cyclohexylamino-6-piperazin-1-yl[2,4']bipyridinyl-4-carboxylic acid amide

Refernces

• 1、 Ngo, Khang,Collins-Kautz, Chelsey,Gerstenecker, Stefan,Wagner, Bj?rn,Heine, Andreas,Klebe, Gerhard. "Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?". . p. 3274 - 3289. Retrieved 2020.
• 2、 Abe, Hajime,Takashima, Shunsuke,Yamamoto, Tsuyoshi,Inouye, Masahiko. "Azacrown-attached meta-ethynylpyridine polymer: Saccharide recognition regulated by supramolecular device". . p. 2121 - 2123. Retrieved 2009.
• 3、 -. "RSV INHIBITING 3-SUBSTITUTED QUINOLINE AND CINNOLINE DERIVATIVES". Page/Page column 124-125. . Retrieved 2021/10/30.