3-(6-chloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane

Base Information

• Chemical Name: 3-(6-chloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane
• CAS No.: 1144080-35-2
• Molecular Formula: C19H24ClN5O3
• Molecular Weight: 405.884
• Mol file: 1144080-35-2.mol

Synonyms:3-[6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-1H-p;

Chemical Property of 3-(6-chloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane

Chemical Property:

• PSA: 74.53000
• Density: 1.71
• LogP: 2.77050

Purity/Quality:

98%min ^*data from raw suppliers

3-(6-Chloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(6-chloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane

There total 1 articles about 3-(6-chloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-yl)-8-oxa-3-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-oxa-3-aza-bicyclo[3.2.1]octane (280-13-7) + 1,4-dioxaspiro[4.5]decan-8-ylhydrazine (1144080-29-4) + 2,4,6-trichloropyrimidine-5-carbaldehyde (50270-27-4) → 6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (1144080-35-2)

Guidance literature:

With triethylamine; In ethanol; water;

DOI:10.1016/j.bmcl.2009.12.086

Reference yield:

6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (1144080-35-2) + 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline (214360-73-3) → 4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]aniline (1144068-84-7)

Guidance literature:

With sodium carbonate; In ethanol; toluene;

DOI:10.1016/j.bmcl.2009.12.086

Reference yield:

6-Chloro-1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidine (1144080-35-2) → C17H20ClN5O2

Guidance literature:

With hydrogenchloride; water;

DOI:10.1016/j.bmcl.2009.12.086

upstream raw materials:

8-oxa-3-aza-bicyclo[3.2.1]octane

1,4-dioxaspiro[4.5]decan-8-ylhydrazine

2,4,6-trichloropyrimidine-5-carbaldehyde

Downstream raw materials:

4-[1-(1,4-dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]aniline