SGI-1776

Base Information

• Chemical Name: SGI-1776
• CAS No.: 1025065-69-3
• Molecular Formula: C20 H22 F3 N5 O
• Molecular Weight: 405.423
• Mol file: 1025065-69-3.mol

Synonyms:SGI-1776;SGI-1776 free base

Chemical Property of SGI-1776

Chemical Property:

• PKA: 9.22±0.10(Predicted)
• PSA: 57.92000
• Density: 1.37
• LogP: 3.40840
• Solubility.: ≥40.5 mg/mL in DMSO; insoluble in H2O; ≥101 mg/mL in EtOH

Purity/Quality:

98%,99%, ^*data from raw suppliers

SGI-1776 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A novel, ATP competitive inhibitor of Pim1, Pim2 and Pim3 with IC50s of 7 nM, 363 nM and 69 nM, respectively. SGI-1776 is a Pim-1 kinase inhibitor. Potent PIM inhibitor.

Technology Process of SGI-1776

There total 1 articles about SGI-1776 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1-(1-methylpiperidin-4-yl)methanamine (7149-42-0) + 6-chloro-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine (928337-00-2) → N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine (1025065-69-3)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In toluene; for 12h; Heating / reflux;

upstream raw materials:

1-(1-methylpiperidin-4-yl)methanamine

6-chloro-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine

Refernces