(1-Methylpiperidin-4-yl)methanamine

Base Information

• Chemical Name: (1-Methylpiperidin-4-yl)methanamine
• CAS No.: 7149-42-0
• Molecular Formula: C7H16 N2
• Molecular Weight: 128.217
• Hs Code.: 2933399090
• European Community (EC) Number: 230-477-2
• NSC Number: 72092
• DSSTox Substance ID: DTXSID50221708
• Nikkaji Number: J227.406J
• Wikidata: Q72495923
• ChEMBL ID: CHEMBL4536092
• Mol file: 7149-42-0.mol

Synonyms:7149-42-0;(1-methylpiperidin-4-yl)methanamine;(1-methyl-4-piperidinyl)methanamine;1-methyl-piperidin-4-methylamine;4-(aminomethyl)-1-methylpiperidine;4-piperidinemethanamine, 1-methyl-;MFCD05022430;1-Methylpiperidine-4-methylamine;1-Methyl-4-(aminomethyl)piperidine;1-(1-methylpiperidin-4-yl)methanamine;C-(1-Methyl-piperidin-4-yl)-methylamine;CHEMBL4536092;4-aminomethyl-1-methylpiperidine;(1-methyl-4-piperidyl)methanamine;EINECS 230-477-2;(1-Methyl-4-piperidinyl)methanamine, AldrichCPR;NSC72092;(1-methyl piperidin-4-yl)methyl amine;SCHEMBL55360;1-Methyl-4-piperidinemethanamine;DTXSID50221708;4-aminomethyl-1-methyl-piperidine;HMS1704I11;(1-methlpiperidin-4-yl)methanamine;1-(methylpiperidin-4-yl)methanamine;4-(aminomethyl)-1-methyl-piperidine;BBL038076;BDBM50520379;N-(1-methyl-4-piperidyl)methylamine;NSC 72092;NSC-72092;STK347047;(1-methylpiperidine-4-yl)methanamine;AKOS000210525;1-(1-Methyl-4-piperidinyl)methanamine;CS-W016551;PB21868;PS-5516;(1-METHYL-4-PIPERIDINYL)METHAN;2-CHLORO-4,6-DINITROBENZOICACID;SY015666;AM20100677;BB 0220168;FT-0648948;EN300-57067;J-500248;F2187-0089

Chemical Property of (1-Methylpiperidin-4-yl)methanamine

Chemical Property:

• Vapor Pressure: 2.47mmHg at 25°C
• Melting Point: 0oC
• Boiling Point: 159.8°Cat760mmHg
• PKA: 10.13±0.29(Predicted)
• Flash Point: 50.3°C
• PSA: 29.26000
• Density: 0.901g/cm³
• LogP: 0.92510
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 75

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1-methyl-4-piperidinyl)methanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xi
• Statements: 34-20/22-22-10
• Safety Statements: 26-36/37/39-45-23

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(CC1)CN
• Uses: (1-methyl-4-piperidinyl)methanamine is a reagent used in the synthesis of novel indole-carboxamides which are inhibitors of neurotropic alphavirus.

Technology Process of (1-Methylpiperidin-4-yl)methanamine

There total 5 articles about (1-Methylpiperidin-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

→ 1-(1-methylpiperidin-4-yl)methanamine (7149-42-0)

Guidance literature:

Reference yield: 21.0%

1-methylpiperidine-4-carboxamide (62718-28-9) → 1-(1-methylpiperidin-4-yl)methanamine (7149-42-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm0204183

Reference yield:

1-methylpiperidine-4-carbonitrile (20691-92-3) → 1-(1-methylpiperidin-4-yl)methanamine (7149-42-0)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

upstream raw materials:

1-methylpiperidine-4-carbonitrile

1-methylpiperidine-4-carboxamide

4-carboxamidopiperidine

Downstream raw materials:

N-{[1-[(2-chlorophenyl)methyl]-4,6-dihydroxy-5-({[(1-methyl-4-piperidinyl)methyl]amino}carbonyl)-2-oxo-1,2-dihydro-3-pyridinyl]carbonyl}glycine

1-(1-(4-chlorobenzyl)-1H-indole-2-carbonyl)-N-((1-methylpiperidin-4-yl)methyl)piperidine-4-carboxamide

1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-N-[(1-methylpiperidin-4-yl)methyl]piperidine-2-carboxamide

4-[1-(4-Chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]-N-[(1-methylpiperidin-4-yl)methyl]piperazine-1-carboxamide

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINES AS CYCLIN-DEPENDENT KINASE INHIBITORS". Page 110-11. . Retrieved 2008/06/13.
• 2、 Sun, Li,Liang, Chris,Shirazian, Sheri,Zhou, Yong,Miller, Todd,Cui, Jean,Fukuda, Juri Y.,Chu, Ji-Yu,Nematalla, Asaad,Wang, Xueyan,Chen, Hui,Sistla, Anand,Luu, Tony C.,Tang, Flora,Wei, James,Tang, Cho. "Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase". . p. 1116 - 1119. Retrieved 2007/10/03.