Ostarine

Base Information

• Chemical Name: Ostarine
• CAS No.: 1235370-13-4
• Molecular Formula: C19H14F3N3O3
• Molecular Weight: 389.33
• Mol file: 1235370-13-4.mol

Synonyms:((2R)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide); GTx-024; MK-2866; (S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide; Ostarine(MK-2866)

Chemical Property of Ostarine

Chemical Property:

• PSA: 109.63000
• Density: 1.41
• LogP: 3.86676

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ostarine

There total 5 articles about Ostarine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

4-cyanophenol (767-00-0) + (2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide (206193-17-1) → Enobosarm (1235370-13-4,841205-47-8)

Guidance literature:

4-cyanophenol; With sodium hydride; In tetrahydrofuran; mineral oil; Inert atmosphere;

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.04.052

Reference yield: 69.7%

4-cyanophenol (767-00-0) + (S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide (113181-02-5) → (R)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide (1132656-73-5,1235370-13-4,841205-47-8)

Guidance literature:

With potassium carbonate; In isopropyl alcohol; for 0.5h; Inert atmosphere; Reflux;

Reference yield:

CH2Cl2/EtOAc + bromoamide + 4-cyanophenol (767-00-0) → Enobosarm (1235370-13-4,841205-47-8)

Guidance literature:

With potassium carbonate; In ethanol; isopropyl alcohol;

upstream raw materials:

4-cyanophenol

(2R)-3-bromo-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

diethyl ether

D-Prolin