Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate

Base Information

Chemical Name:Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate
CAS No.:1202889-58-4
Molecular Formula:C12H13ClO4
Molecular Weight:256.686
Hs Code.:
Mol file:1202889-58-4.mol

Synonyms:ethyl 6-chloro-7-hydroxychroman-4-carboxylate;Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate;6-chloro-2-ethyl-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-carboxylate;2H-1-Benzopyran-4-carboxylic acid, 6-chloro-3,4-dihydro-7-hydroxy-, ethyl ester

Suppliers and Price of Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 1 raw suppliers

Chemical Property of Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate

Chemical Property:

PSA：55.76000
LogP:2.47480

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate

There total 6 articles about Ethyl-6-chloro-7-hydroxy-3,4-dihydro-2H-chromene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 64-17-5
ethanol

: 1202889-64-2
6-chloro-7-hydroxychroman-4-carboxylic acid dicyclohexylamine

: 1202889-58-4
ethyl 6-chloro-7-hydroxychroman-4-carboxylate

Guidance literature:: 6-chloro-7-hydroxychroman-4-carboxylic acid dicyclohexylamine; With sodium hydroxide; In water; Industry scale;

With hydrogenchloride; In water; pH=2 - 3; Industry scale;

ethanol; With sulfuric acid; for 16h; Reflux;

Reference yield: 43.0%

: 64-17-5
ethanol

: 1202889-63-1
6-chloro-7-hydroxychroman-4-carboxylic acid

: 1202889-58-4
ethyl 6-chloro-7-hydroxychroman-4-carboxylate

Guidance literature:: With sulfuric acid; for 16h; Product distribution / selectivity; Reflux; Industry scale;

Reference yield:

: 74277-66-0
6-chloro-7-hydroxychroman-4-one

: 1202889-58-4
ethyl 6-chloro-7-hydroxychroman-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine / dichloromethane / 10 - 20 °C / Inert atmosphere; Industry scale

1.2: 20 °C / Industry scale

2.1: hydrogenchloride; tin(II) chloride dihdyrate; water / acetic acid / 18 h / 100 °C / Industry scale

2.2: 1 h / 20 °C / Industry scale

3.1: sodium hydroxide / water / Industry scale

3.2: pH 2 - 3 / Industry scale

3.3: 16 h / Reflux

With hydrogenchloride; tin(II) chloride dihdyrate; water; iodine; sodium hydroxide; In dichloromethane; water; acetic acid;