5-bromo-2-phenoxypyridine

Base Information

• Chemical Name: 5-bromo-2-phenoxypyridine
• CAS No.: 59717-96-3
• Molecular Formula: C11H8BrNO
• Molecular Weight: 250.095
• Hs Code.: 2933399990
• Mol file: 59717-96-3.mol

Synonyms:2-phenoxy-5-bromopyridine;QC-3579;5-bromo-2-phenoxy-pyridine;

Chemical Property of 5-bromo-2-phenoxypyridine

Chemical Property:

• Boiling Point: 310.0±22.0 °C(Predicted)
• PKA: 0.18±0.22(Predicted)
• PSA: 22.12000
• Density: 1.476±0.06 g/cm3(Predicted)
• LogP: 3.63640
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-phenoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-phenoxypyridine

There total 4 articles about 5-bromo-2-phenoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,5-dibromopyridine (624-28-2) + phenol (108-95-2,27073-41-2) → 5-bromo-2-phenoxypyridine (59717-96-3)

Guidance literature:

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; caesium carbonate; In dimethyl sulfoxide; at 110 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2012.10.025

Reference yield: 95.0%

5-bromo-2-fluoropyridine (766-11-0) + phenol (108-95-2,27073-41-2) → 5-bromo-2-phenoxypyridine (59717-96-3)

Guidance literature:

phenol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Reflux;

5-bromo-2-fluoropyridine; In tetrahydrofuran; for 12h; Reflux;

DOI:10.1016/j.ejmech.2015.02.056

Reference yield: 81.0%

→ 5-bromo-2-phenoxypyridine (59717-96-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 115 ℃; for 16h;

upstream raw materials:

2,5-dibromopyridine

phenol

5-bromo-2-fluoropyridine

Downstream raw materials:

2-phenoxy-5-thiophen-2-ylpyridine

5-butyl-2-phenoxypyridine

5-ethyl-2-phenoxypyridine

2-phenoxy-5-phenylpyridine

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