1-Cbz-3-Boc-Amino pyrrolidine

Base Information

Chemical Name:1-Cbz-3-Boc-Amino pyrrolidine
CAS No.:185057-49-2
Molecular Formula:C17H24N2O4
Molecular Weight:320.389
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60939923
Mol file:185057-49-2.mol

Synonyms:185057-49-2;1-Cbz-3-Boc-Amino pyrrolidine;3-(Boc-amino)-1-Cbz-pyrrolidine;1-Cbz-3-Boc-aminopyrrolidine;benzyl 3-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidine-1-carboxylate;MFCD08704348;(R)-3-(Boc-amino)-1-Cbz-pyrrolidine;VCCUTXNUDLVCTI-UHFFFAOYSA-N;SCHEMBL953899;DTXSID60939923;benzyl 3-{[(tert-butoxy)carbonyl]amino}pyrrolidine-1-carboxylate;3-tert-Butoxycarbonylamino-pyrrolidine-1-carboxylic acid benzyl ester;(S)-1-Cbz-3-(Boc-amino)pyrrolidine;AKOS017342981;AB48529;SY020389;SY284240;1-cbz-3-(t-butyloxycarbonyl)aminopyrrolidine;CS-0448732;EN300-180513;Benzyl 3-((tert-butoxycarbonyl)amino)pyrrolidine-1-carboxylate;Benzyl 3-{[tert-butoxy(hydroxy)methylidene]amino}pyrrolidine-1-carboxylate

Suppliers and Price of 1-Cbz-3-Boc-Amino pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Cbz-3-Boc-aminopyrrolidine 97%
25g
$ 447.00

American Custom Chemicals Corporation
3-TERT-BUTOXYCARBONYLAMINO-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER 95.00%
5G
$ 952.01

Total 10 raw suppliers

Chemical Property of 1-Cbz-3-Boc-Amino pyrrolidine

Chemical Property:

Boiling Point:458.496 °C at 760 mmHg
Flash Point:231.091 °C
PSA：71.36000
Density:1.174 g/cm³
LogP:3.06450
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:320.17360725
Heavy Atom Count:23
Complexity:413

Purity/Quality:

97% ^*data from raw suppliers

1-Cbz-3-Boc-aminopyrrolidine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCN(C1)C(=O)OCC2=CC=CC=C2

Technology Process of 1-Cbz-3-Boc-Amino pyrrolidine

There total 6 articles about 1-Cbz-3-Boc-Amino pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 99724-19-3,140629-77-2
3-(tert-butoxycarbonylamino)pyrrolidine

: 501-53-1,94274-21-2
benzyl chloroformate

: 185057-49-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinecarboxylic acid,phenylmethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 66.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 68471-57-8
2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester

: 185057-49-2
(S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinecarboxylic acid,phenylmethyl ester

Guidance literature:: 2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester; With iridium(lll) bis[2-(2,4-difluorophenyl)-5-methylpyridine-N,C₂₀]-4,40-di-tert-butyl-2,20-bipyridine hexafluorophosphate; 2,4,6-Triisopropylthiophenol; ammonia; In methanol; toluene; at 20 ℃; for 16h; Inert atmosphere; Irradiation;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; toluene; at 20 ℃; for 16h; regioselective reaction;
DOI:10.1002/chem.202003562