(S)-1-(4-chlorophenyl)propan-1-aMine-hcl

Base Information

• Chemical Name: (S)-1-(4-chlorophenyl)propan-1-aMine-hcl
• CAS No.: 114853-62-2
• Molecular Formula: C9H12ClN
• Molecular Weight: 206.11222
• Mol file: 114853-62-2.mol

Synonyms:(S)-1-(4-chlorophenyl)propan-1-aMine-hcl;(S)-1-(4-Chlorophenyl)propan-1-aMine hydrochloride

Chemical Property of (S)-1-(4-chlorophenyl)propan-1-aMine-hcl

Chemical Property:

• Boiling Point: 244.3±15.0 °C(Predicted)
• PKA: 9.13±0.10(Predicted)
• PSA: 26.02000
• Density: 1.093±0.06 g/cm3(Predicted)
• LogP: 4.25210
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(S)-1-(4-Chlorophenyl)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-(4-chlorophenyl)propan-1-aMine-hcl

There total 11 articles about (S)-1-(4-chlorophenyl)propan-1-aMine-hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 1-(4-chlorophenyl)propan-1-amine (74788-46-8,114853-62-2)

Guidance literature:

With {RuCl(p-cymene)((S)-2,2'-bis(di-p-tolylphosphino)-1,1'-binaphthyl)}Cl; ammonia; hydrogen; ammonium chloride; In methanol; water; at 90 ℃; for 48h; under 30003 Torr; Autoclave; Inert atmosphere;

Reference yield: 92.0%

N-[1-(4-chlorophenyl)ethyl]methoxyacetamide (192210-96-1) → (R)-1-(4-chlorophenyl)propan-1-amine (114853-61-1,114853-62-2)

Guidance literature:

With sodium hydroxide; triethanolamine; In water; at 85 - 120 ℃; for 2h;

Reference yield: 83.0%

triethyl borane (97-94-9) + (1S,3S,4R)-2-(4-chlorophenylmethyl)-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate → (R)-1-(4-chlorophenyl)propan-1-amine (114853-61-1,114853-62-2)

Guidance literature:

(1S,3S,4R)-2-(4-chlorophenylmethyl)-3-[(1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]-2-thioniabicyclo[2.2.1]heptane tetrafluoroborate; With lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; at -78 ℃; for 1h;

triethyl borane; In tetrahydrofuran; dichloromethane; at -100 - 0 ℃;

With hydroxylamine-O-sulfonic acid; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Further stages.;

DOI:10.1021/ja074110i

upstream raw materials:

4'-chloropropiophenone

ammonium formate

ethylmagnesium bromide

N-(4-chlorobenzylidene)-N-(1,1,1-trimethylsilyl)amine

Downstream raw materials:

4-amino-N-(1-(4-chlorophenyl)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

3-[1-(4-Chloro-phenyl)-propyl]-1-(2-hydroxy-ethyl)-1-methyl-thiourea

Refernces

• 1、 -. "MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF". Paragraph 0387. . Retrieved 2021/01/23.
• 2、 Issaraseriruk, Natthapol,Sritana-anant, Yongsak,Shitangkoon, Aroonsiri. "Substituent effects on chiral resolutions of derivatized 1-phenylalkylamines by heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-cyclodextrin GC stationary phase". supporting information. p. 900 - 906. Retrieved 2018/05/08.