2-AMino-5-Methyloxazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-AMino-5-Methyloxazole-4-carboxylic acid ethyl ester
• CAS No.: 1065099-78-6
• Molecular Formula: C7H10N2O3
• Molecular Weight: 170.1659
• Mol file: 1065099-78-6.mol

Synonyms:ethyl 2-amino-5-methyl-oxazole-4-carboxylate;

Chemical Property of 2-AMino-5-Methyloxazole-4-carboxylic acid ethyl ester

Chemical Property:

• PSA: 79.08000
• LogP: 0.67200

Purity/Quality:

99.5% ^*data from raw suppliers

2-Amino-5-methyl-oxazole-4-carboxylicacidethylester 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-5-Methyloxazole-4-carboxylic acid ethyl ester

There total 2 articles about 2-AMino-5-Methyloxazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-bromo-2-oxo-butyric acid ethyl ester (57332-84-0) + urea (57-13-6) → ethyl 2-amino-5-methyloxazole-4-carboxylate (1065099-78-6)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmcl.2009.01.060

Reference yield:

Ethyl 2-oxobutanoate (15933-07-0) → ethyl 2-amino-5-methyloxazole-4-carboxylate (1065099-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate; dichloromethane / 80 °C

2: ethanol / 90 °C

With copper(ll) bromide; In ethanol; dichloromethane; ethyl acetate;

Reference yield: 80.0%

ethyl 2-amino-5-methyloxazole-4-carboxylate (1065099-78-6) → ethyl 2-chloro-5-methyloxazole-4-carboxylate (1144520-57-9)

Guidance literature:

With tert.-butylnitrite; copper dichloride; In acetonitrile; at 80 ℃;

DOI:10.1016/j.bmcl.2009.01.060

upstream raw materials:

3-bromo-2-oxo-butyric acid ethyl ester

urea

Ethyl 2-oxobutanoate

Downstream raw materials:

ethyl 2-chloro-5-methyloxazole-4-carboxylate

Refernces

• 1、 Lee, Sunkyung,Yi, Kyu Yang,Youn, Sung Jun,Lee, Byung Ho,Yoo, Sung-eun. "(2-Aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-aryl-5-methyloxazol-4-ylcarbonyl)guanidines as NHE-1 inhibitors". scheme or table. p. 1329 - 1331. Retrieved 2009/10/02.