(3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole

Base Information

Chemical Name:(3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole
CAS No.:229184-98-9
Molecular Formula:C23H20N2O2
Molecular Weight:356.42
Hs Code.:

Synonyms:(3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole;8H-Indeno[1,2-d]oxazole, 2,2'-cyclopropylidenebis[3a,8a-dihydro-, (3aR,3'aR,8aS,8'a'S)-;(3aR,3a'R,8aS,8a'S)-2,2'-(cyclopropane-1,1-diyl)bis(3a,8a-dihydro-8H-indeno[1,2-d]oxazole);(3aR,3a'R,8aS,8a'S)-2,2'-(Cyclopropane-1,1-diyl)bis(8,8a-dihydro-3aH-indeno[1,2-d]oxazole);(3aR,3'aR,8aS,8'aS)-2,2'-Cyclopropylidenebis[3a,8a-dihyd ro-8H-Indeno[1,2-d]oxazole],99%e.e.;(3aR,3'aR,8aS,8'a'S)-2,2'-Cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole], 98%, (99% ee)

Suppliers and Price of (3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Strem Chemicals
(3aR,3'aR,8aS,8'a'S)-2,2'-Cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole], 98%, (99% ee) 8a-dihydro-8H-Indeno[1,2-d]oxazole], 98%, (99% ee)
50mg
$ 170.00

Total 12 raw suppliers

Chemical Property of (3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole

Chemical Property:

Boiling Point:520.4±50.0 °C(Predicted)
PKA:5.98±0.20(Predicted)
PSA：43.18000
Density:1.54±0.1 g/cm3(Predicted)
LogP:2.82720
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(3aR,3'aR,8aS,8'a'S)-2,2'-Cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole], 98%, (99% ee) 8a-dihydro-8H-Indeno[1,2-d]oxazole], 98%, (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole

There total 8 articles about (3aR,3'aR,8aS,8'a'S)-2,2'-cyclopropylidenebis[3a,8a-dihydro-8H-Indeno[1,2-d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 106-93-4
ethylene dibromide

: 180186-94-1
bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane

: 229184-98-9
(3aR,3'aR,8aS,8'aS)-2,2'-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]oxazole

Guidance literature:: bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

ethylene dibromide; In tetrahydrofuran; mineral oil; at 20 - 50 ℃; for 3.25h;

Reference yield: 85.0%

: 106-93-4
ethylene dibromide

: 175166-49-1
[3aS-[2(3'aR*,8'aS*),3a,8a]]methylenebis[3a,8a-dihydro-8H-indeno[1,2-d]oxazole]

: 229184-98-9
{3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ja026788y

Reference yield:

: 7480-35-5,13286-59-4,74165-73-4,126456-43-7,136030-00-7,140632-19-5,140632-20-8
(1S,2R)-1-amino-2-indanol

: 229184-98-9
{3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / tetrahydrofuran / 4 h

2: 85 percent / LiHMDS / tetrahydrofuran

With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ja026788y