diethyl 2-bromo-5-chloroterephthalate

Base Information

• Chemical Name: diethyl 2-bromo-5-chloroterephthalate
• CAS No.: 340148-60-9
• Molecular Formula: C₁₂H₁₂BrClO₄
• Molecular Weight: 335.582
• Hs Code.: 2917399590
• Mol file: 340148-60-9.mol

Synonyms:diethyl 2-broMo-5-chloroterephthalate;2-Bromo-5-chloroterephthalic acid diethyl ester;Diethyl 2-bromo-5-chlorobenzene-1,4- dicarboxylate;1,4-Benzenedicarboxylic acid, 2-bromo-5-chloro-, 1,4-diethyl ester

Chemical Property of diethyl 2-bromo-5-chloroterephthalate

Chemical Property:

• PSA: 52.60000
• LogP: 3.45590

Purity/Quality:

99% ^*data from raw suppliers

Diethyl2-bromo-5-chloroterephthalate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 2-bromo-5-chloroterephthalate

There total 3 articles about diethyl 2-bromo-5-chloroterephthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-chloro-2,5-dimethylbenzene (85072-44-2) → 2-bromo-5-chloroterephthalic acid diethyl ester (340148-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water; tert-butyl alcohol / 19 h / Reflux

2: sulfuric acid / 18 h / Reflux

With potassium permanganate; sulfuric acid; In water; tert-butyl alcohol; 2: |Fischer-Speier Esterification;

DOI:10.1021/acs.joc.6b00340

Reference yield:

2-chloro-1,4-dimethyl-benzene (95-72-7) → 2-bromo-5-chloroterephthalic acid diethyl ester (340148-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: iodine; bromine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere; Darkness

2: potassium permanganate / water; tert-butyl alcohol / 19 h / Reflux

3: sulfuric acid / 18 h / Reflux

With potassium permanganate; sulfuric acid; bromine; iodine; In dichloromethane; water; tert-butyl alcohol; 3: |Fischer-Speier Esterification;

DOI:10.1021/acs.joc.6b00340

Reference yield:

ethanol (64-17-5) + 2-bromo-5-chloro-terephthalic acid (500550-60-7) → 2-bromo-5-chloroterephthalic acid diethyl ester (340148-60-9)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethanol

2-bromo-5-chloro-terephthalic acid

1-bromo-4-chloro-2,5-dimethylbenzene

2-chloro-1,4-dimethyl-benzene

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