1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER

Base Information

• Chemical Name: 1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER
• CAS No.: 439858-36-3
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.293
• Mol file: 439858-36-3.mol

Synonyms:1-Hydroxy-2,2,6,6-tetramethyl-piperidine-4-carboxylic acid methyl ester;1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER;1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE METHYL ESTER;4-(methoxycarbonyl)-2,2,6,6-tetramethylpiperidin-1-yloxy;1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER,OIL;

Chemical Property of 1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER

Chemical Property:

• PSA: 49.77000
• LogP: 1.75570

Purity/Quality:

98% ^*data from raw suppliers

1-Hydroxy-4-carboxyl-2,2,6,6-tetramethylpiperidine,MethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER

There total 1 articles about 1-HYDROXY-4-CARBOXYL-2,2,6,6-TETRAMETHYLPIPERIDINE, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 1-oxyl-4-carboxyl-2,2,6,6-tetramethylpiperidine (37149-18-1) → 1-hydroxy-4-carbamoyl-2,2,6,6,-tetramethylpiperidine methyl ester (439858-36-3)

Guidance literature:

With hydrogenchloride; for 0.5h;

DOI:10.1021/jm0105169

Reference yield: 67.0%

acetic anhydride (108-24-7) + 1-hydroxy-4-carbamoyl-2,2,6,6,-tetramethylpiperidine methyl ester (439858-36-3) → AMCPe (439858-37-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1021/jm0105169

Reference yield:

(4-Bromo-2,6-di-tert-butylphenoxy)trimethylsilane (27329-74-4) + 1-hydroxy-4-carbamoyl-2,2,6,6,-tetramethylpiperidine methyl ester (439858-36-3) → 4-<(3,5-di-tert-butyl-4-hydroxyphenyl)(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)methyl>-2,2,6,6-tetramethylpiperidin-1-yloxy (81769-84-8)

Guidance literature:

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; Yield given. Multistep reaction; 1.) n-hexane, 2.) CH₃OH;

DOI:10.1021/ja00378a013

upstream raw materials:

methanol

1-oxyl-4-carboxyl-2,2,6,6-tetramethylpiperidine

Downstream raw materials:

4-<(3,5-di-tert-butyl-4-hydroxyphenyl)(3,5-di-tert-butyl-4-oxocyclohexa-2,5-dienylidene)methyl>-2,2,6,6-tetramethylpiperidin-1-yloxy

AMCPe

Refernces