ETHYL 2-BROMO-PHENYLBUTANATE ESTER

Base Information

• Chemical Name: ETHYL 2-BROMO-PHENYLBUTANATE ESTER
• CAS No.: 914226-08-7
• Molecular Formula: C₁₂H₁₅BrO₂
• Molecular Weight: 271.154
• Mol file: 914226-08-7.mol

Synonyms:Ethyl 2-bromo-phenylbutanateester;

Chemical Property of ETHYL 2-BROMO-PHENYLBUTANATE ESTER

Chemical Property:

• PSA: 26.30000
• LogP: 3.33490

Purity/Quality:

98%Min ^*data from raw suppliers

BENZENEBUTANOICACID,2-BROMO-,ETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-BROMO-PHENYLBUTANATE ESTER

There total 7 articles about ETHYL 2-BROMO-PHENYLBUTANATE ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diazoacetic acid ethyl ester (623-73-4) + 2-bromostyrene (2039-88-5) → ethyl 4-(2-bromophenyl)butanoate (914226-08-7)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; para-thiocresol; In dichloromethane; at 25 ℃; for 12h; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.0c05183

Reference yield:

ethanol (64-17-5) + 4-(2-bromophenyl)butanoic acid (90841-47-7) → ethyl 4-(2-bromophenyl)butanoate (914226-08-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.08.031

Reference yield:

ethanol (64-17-5) + 2-(2-(o-bromophenyl)ethyl)-malonic acid (92013-29-1) → ethyl 4-(2-bromophenyl)butanoate (914226-08-7)

Guidance literature:

2-(2-(o-bromophenyl)ethyl)-malonic acid; at 170 ℃; for 0.5h;

ethanol; With thionyl chloride;

DOI:10.1016/j.ejmech.2014.08.031

upstream raw materials:

2-(2-(o-bromophenyl)ethyl)-malonic acid

2-bromophenylethyl alcohol

2-(2'bromophenyl)-1-iodoethane

1,1-bis(ethoxycarbonyl)-3-(2'-bromophenyl)propane

Refernces

• 1、 Liu, Chao,Zhao, Guo-Dong,Mao, Xinliang,Suenaga, Tsutomu,Fujishima, Toshie,Zhang, Cheng-Mei,Liu, Zhao-Peng. "Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D 3 analogues with aromatic side chains attached at C-17". . p. 569 - 575. Retrieved 2014/11/07.