1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 208242-25-5
• Molecular Formula: C6H7F3O2
• Molecular Weight: 168.11
• Hs Code.: 2916209090
• Mol file: 208242-25-5.mol

Synonyms:METHYL 1-(TRIFLUOROMETHYL)CYCLOPROPANE-1-CARBOXYLATE;;

Chemical Property of 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 35.7mmHg at 25°C
• Refractive Index: n20/D 1.373
• Boiling Point: 64-66
• Flash Point: 115°C
• PSA: 26.30000
• Density: 1.241 g/mL at 25 °C
• LogP: 1.50190
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(Trifluoromethyl)cyclopropane-1-carboxylicacidmethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22-10
• Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER

There total 1 articles about 1-TRIFLUOROMETHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-(trifluoromethyl)cyclopropanecarboxylic acid (277756-46-4) → methayl 1-(trifluoromethyl)cyclopropanecarboxylate (208242-25-5)

Guidance literature:

In methanol; hexane;

Reference yield: 64.0%

methayl 1-(trifluoromethyl)cyclopropanecarboxylate (208242-25-5) → 1-Hydroxymethyl-1-(trifluoromethyl)cyclopropane (371917-17-8)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

methayl 1-(trifluoromethyl)cyclopropanecarboxylate (208242-25-5) → phenyl 5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-ylcarbamate (1188920-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 15.75 h / 70 - 75 °C

2.1: sodium hydrogencarbonate; hydroxylamine sulfate / methanol; water / 15 h / 65 °C

2.2: 0.08 h / 140 °C / 5250.53 Torr

3.1: potassium carbonate / tetrahydrofuran / 18.5 h / 20 °C

With sodium hydride; sodium hydrogencarbonate; potassium carbonate; hydroxylamine sulfate; In tetrahydrofuran; methanol; water; mineral oil;

DOI:10.1021/jm2009925

upstream raw materials:

diazomethane

1-(trifluoromethyl)cyclopropanecarboxylic acid

Downstream raw materials:

1-Hydroxymethyl-1-(trifluoromethyl)cyclopropane

phenyl 5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-ylcarbamate

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