N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine drochloride

Base Information

• Chemical Name: N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine drochloride
• CAS No.: 851684-46-3
• Molecular Formula: C21H15Cl2FIN3O
• Molecular Weight: 542.179
• Mol file: 851684-46-3.mol

Synonyms:N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine drochloride;

Chemical Property of N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine drochloride

Chemical Property:

• PSA: 47.04000
• LogP: 7.22450
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-iodoquinazolin-4-amineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine drochloride

There total 4 articles about N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine drochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-chloro-6-iodoquinazoline hydrochloride (1373622-18-4) + 3-chloro-4-(3-fluorobenzyloxy)aniline (202197-26-0) → N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine hydrochloride (851684-46-3)

Guidance literature:

In isopropyl alcohol; at 80 ℃; for 12h;

DOI:10.1021/jm400349k

Reference yield: 70.0%

4-chloro-6-iodoquinazoline (98556-31-1) + 3-chloro-4-(3-fluorobenzyloxy)aniline (202197-26-0) → N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine hydrochloride (851684-46-3)

Guidance literature:

In isopropyl alcohol; for 4h; Heating / reflux;

Reference yield:

2-amino-5-iodobenzoic acid (5326-47-6) → N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-iodoquinazolin-4-amine hydrochloride (851684-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 4 h / 170 °C

2: thionyl chloride / N,N-dimethyl-formamide / 12 h / 80 °C

3: isopropyl alcohol / 12 h / 80 °C

With thionyl chloride; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm400349k

upstream raw materials:

4-chloro-6-iodoquinazoline

3-chloro-4-(3-fluorobenzyloxy)aniline

4-chloro-6-iodoquinazoline hydrochloride

2-amino-5-iodobenzoic acid

Downstream raw materials:

5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carbaldehyde

5-{4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-carboxylic acid methoxy-methyl-amide

(3-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-carbamic acid tert-butyl ester

(5-{4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-furan-2-ylmethyl)-carbamic acid tert-butyl ester