[R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one

Base Information

• Chemical Name: [R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one
• CAS No.: 188559-25-3
• Molecular Formula: C39H39NO3
• Molecular Weight: 569.744
• Mol file: 188559-25-3.mol

Synonyms:[R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one

Chemical Property of [R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one

Chemical Property:

• PSA: 49.77000
• LogP: 8.54090
• Solubility.: Dichloromethane, Diethyl Ether, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

[R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one

There total 5 articles about [R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-pent-2-enoyl chloride (33698-85-0) → (R)-3-[(R)-1-(3-Dibenzylamino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-prop-1-ynyl-5,6-dihydro-pyran-2-one (188559-25-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / n-BuLi / tetrahydrofuran / -78 °C

2: CuBr, DMS / tetrahydrofuran / 1 h / 0 °C

3: 1.) H₃O⁺, 2.) Na₂CO₃ / 2.) H₂O, CH₂Cl₂

6: 67 percent / t-BuOK / tetrahydrofuran / 0 °C

With n-butyllithium; 2,3-dimercapto-succinic acid; oxonium; potassium tert-butylate; sodium carbonate; copper(I) bromide; In tetrahydrofuran;

DOI:10.1021/ja963434w

Reference yield:

(R)-3-{(S)-3-[3-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-pentanoyl}-4-phenyl-oxazolidin-2-one → (R)-3-[(R)-1-(3-Dibenzylamino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-prop-1-ynyl-5,6-dihydro-pyran-2-one (188559-25-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) H₃O⁺, 2.) Na₂CO₃ / 2.) H₂O, CH₂Cl₂

4: 67 percent / t-BuOK / tetrahydrofuran / 0 °C

With oxonium; potassium tert-butylate; sodium carbonate; In tetrahydrofuran;

DOI:10.1021/ja963434w

Reference yield:

(R)-3-[(S)-3-(3-Dibenzylamino-phenyl)-pentanoyl]-4-phenyl-oxazolidin-2-one (174590-40-0) → (R)-3-[(R)-1-(3-Dibenzylamino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-prop-1-ynyl-5,6-dihydro-pyran-2-one (188559-25-3)

Guidance literature:

Multi-step reaction with 3 steps

3: 67 percent / t-BuOK / tetrahydrofuran / 0 °C

With potassium tert-butylate; In tetrahydrofuran;

DOI:10.1021/ja963434w

upstream raw materials:

(E)-pent-2-enoyl chloride

(R)-3-[(S)-3-(3-Dibenzylamino-phenyl)-pentanoyl]-4-phenyl-oxazolidin-2-one

(S)-2-[(S)-1-(3-Dibenzylamino-phenyl)-propyl]-1-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-butane-1,3-dione

(R)-N-[(E)-EtCHCHC(O)]-4-phenyl-1,3-oxazolidin-2-one

Downstream raw materials:

tipranavir

(R)-3-[(R)-1-(3-Amino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 188559-25-3 [R-(R*,R*)]-3-[1-[3-[Bis(phenylmethyl)amino]phenyl]propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-(1-propynyl)-2H-pyran-2-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send