3-[(1R)-1-(3-aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-, (6R)- 2H-Pyran-2-one

Base Information

Chemical Name:3-[(1R)-1-(3-aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-, (6R)- 2H-Pyran-2-one
CAS No.:174485-90-6
Molecular Formula:C25H31NO3
Molecular Weight:393.526
Hs Code.:

Synonyms:Reaxys ID: 7724109;(6R)-3-[(1R)-1-(3-Aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-2H-pyran-2-one

Suppliers and Price of 3-[(1R)-1-(3-aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-, (6R)- 2H-Pyran-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 3-[(1R)-1-(3-aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-, (6R)- 2H-Pyran-2-one

Chemical Property:

PSA：72.55000
LogP:6.27430

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-[(1R)-1-(3-aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-, (6R)- 2H-Pyran-2-one

There total 21 articles about 3-[(1R)-1-(3-aminophenyl)propyl]-5,6-dihydro-4-hydroxy-6-(2-phenylethyl)-6-propyl-, (6R)- 2H-Pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188559-25-3
(R)-3-[(R)-1-(3-Dibenzylamino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-prop-1-ynyl-5,6-dihydro-pyran-2-one

: 174485-90-6
(R)-3-[(R)-1-(3-Amino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1021/ja963434w

Reference yield:

: 33698-85-0
(E)-pent-2-enoyl chloride

: 174485-90-6
(R)-3-[(R)-1-(3-Amino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / n-BuLi / tetrahydrofuran / -78 °C

2: CuBr, DMS / tetrahydrofuran / 1 h / 0 °C

3: 1.) H₃O⁺, 2.) Na₂CO₃ / 2.) H₂O, CH₂Cl₂

6: 67 percent / t-BuOK / tetrahydrofuran / 0 °C

7: H₂ / Pd/C / methanol; ethyl acetate

With n-butyllithium; 2,3-dimercapto-succinic acid; oxonium; potassium tert-butylate; hydrogen; sodium carbonate; copper(I) bromide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/ja963434w

Reference yield:

: (R)-3-{(S)-3-[3-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-pentanoyl}-4-phenyl-oxazolidin-2-one

: 174485-90-6
(R)-3-[(R)-1-(3-Amino-phenyl)-propyl]-4-hydroxy-6-phenethyl-6-propyl-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) H₃O⁺, 2.) Na₂CO₃ / 2.) H₂O, CH₂Cl₂

4: 67 percent / t-BuOK / tetrahydrofuran / 0 °C

5: H₂ / Pd/C / methanol; ethyl acetate

With oxonium; potassium tert-butylate; hydrogen; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/ja963434w