3-(4-Bromophenyl)-4H-1,2,4-triazole

Base Information

• Chemical Name: 3-(4-Bromophenyl)-4H-1,2,4-triazole
• CAS No.: 118863-62-0
• Molecular Formula: C8H6BrN3
• Molecular Weight: 224.06
• Hs Code.: 2933990090
• Mol file: 118863-62-0.mol

Synonyms:3-(4-Bromophenyl)-4H-1,2,4-triazole;5-(4-broMophenyl)-1H-1,2,4-triazole

Chemical Property of 3-(4-Bromophenyl)-4H-1,2,4-triazole

Chemical Property:

• Boiling Point: 376.7±44.0 °C(Predicted)
• PKA: 9.28±0.20(Predicted)
• PSA: 41.57000
• Density: 1.651±0.06 g/cm3(Predicted)
• LogP: 2.23420
• Storage Temp.: Room temperature.

Purity/Quality:

97% ^*data from raw suppliers

3-(4-Bromophenyl)-1H-[1,2,4]triazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Bromophenyl)-4H-1,2,4-triazole

There total 13 articles about 3-(4-Bromophenyl)-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-4-bromo-N-((dimethylamino)methylene)benzamide (1269646-41-4) → 3-(4-bromophenyl)-1H-1,2,4-triazole (118863-62-0)

Guidance literature:

With hydrazine hydrate; acetic acid; at 90 ℃; for 2h;

Reference yield: 91.0%

hydrazine hydrate (79785-97-0) + (E)-4-bromo-N-((dimethylamino)methylene)benzamide (1269646-41-4) → 3-(4-bromophenyl)-1H-1,2,4-triazole (118863-62-0)

Guidance literature:

With 2'-methyl-N-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)[1,1'-biphenyl]-3-carboxamide; In acetic acid; at 90 ℃; for 3h; Cooling with ice;

Reference yield: 66.0%

(E)-4-bromo-N-((dimethylamino)methylene)benzamide (1269646-41-4) → 5-(4-bromophenyl)-1H-1,2,4-triazole (118863-62-0)

Guidance literature:

With hydrazine hydrate; acetic acid; at 90 ℃; for 1.5h;

upstream raw materials:

3-diazo-3H-[1,2,4]triazole

bromobenzene

p-bromobenzamide

(E)-4-bromo-N-((dimethylamino)methylene)benzamide

Downstream raw materials:

(S)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one

(S)-4-isopropyl-3-(3-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazol-5-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)oxazolidin-2-one

(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-isopropyloxazolidin-2-one

3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-1,2,4-triazole