2-(2,6-difluorophenyl)propanoic Acid

Base Information

Chemical Name:2-(2,6-difluorophenyl)propanoic Acid
CAS No.:359828-68-5
Molecular Formula:C9H8F2O2
Molecular Weight:186.158
Hs Code.:2916399090
European Community (EC) Number:848-626-0
DSSTox Substance ID:DTXSID10452536
Mol file:359828-68-5.mol

Synonyms:2-(2,6-difluorophenyl)propanoic Acid;359828-68-5;2-(2,6-Difluoro-phenyl)-propionic acid;2-(2,6-Difluorophenyl)propanoicacid;SCHEMBL15645912;DTXSID10452536;JEOKHTAAVBOFKM-UHFFFAOYSA-N;MFCD11036843;2-(2,6-Difluorophenyl)propionic acid;AKOS013353366;BS-44332;A6252;(2rs)-2-(2,6-difluorophenyl)propanoic acid;EN300-122564;J-505505;Z1188090603

Suppliers and Price of 2-(2,6-difluorophenyl)propanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(2,6-difluorophenyl)propanoicacid
10mg
$ 45.00

Crysdot
2-(2,6-Difluorophenyl)propanoicacid 95+%
1g
$ 353.00

Chemcia Scientific
2-(2,6-Difluoro-phenyl)-propionicacid ＞97%
0.1 G
$ 120.00

Atlantic Research Chemicals
2-(2,6-Difluorophenyl)propanoicacid 95%
1gm:
$ 562.00

American Custom Chemicals Corporation
2-(2,6-DIFLUOROPHENYL)PROPANOIC ACID 95.00%
5MG
$ 499.15

Alichem
2-(2,6-Difluorophenyl)propanoicacid
1g
$ 296.64

AK Scientific
2-(2,6-Difluorophenyl)propanoicacid
1g
$ 1005.00

AK Scientific
2-(2,6-Difluorophenyl)propanoicacid
500mg
$ 786.00

AK Scientific
2-(2,6-Difluorophenyl)propanoicacid
250mg
$ 481.00

Total 10 raw suppliers

Chemical Property of 2-(2,6-difluorophenyl)propanoic Acid

Chemical Property:

PSA：37.30000
LogP:2.15290
Storage Temp.:2-8°C
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:186.04923582
Heavy Atom Count:13
Complexity:186

Purity/Quality:

97% ^*data from raw suppliers

2-(2,6-difluorophenyl)propanoicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=C(C=CC=C1F)F)C(=O)O

Technology Process of 2-(2,6-difluorophenyl)propanoic Acid

There total 4 articles about 2-(2,6-difluorophenyl)propanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 654-01-3
(2,6-difluorophenyl)acetonitrile

: 616-38-6
carbonic acid dimethyl ester

: 359828-68-5
(2RS)-2-(2,6-difluorophenyl)propanoic acid

Guidance literature:: (2,6-difluorophenyl)acetonitrile; carbonic acid dimethyl ester; With potassium carbonate; at 190 - 200 ℃; for 6.5h; High-pressure reactor;

With sodium hydroxide; In water; for 16h; Heating;

With hydrogenchloride; In water; pH=1;
DOI:10.1134/S1070428009100194

Reference yield:

: C₁₁H₁₂F₂O₂

: 359828-68-5
(2RS)-2-(2,6-difluorophenyl)propanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmcl.2021.128266

Reference yield:

: 680217-71-4
(2,6-difluorophenyl)acetic acid ethyl ester

: 359828-68-5
(2RS)-2-(2,6-difluorophenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 °C

2: lithium hydroxide / tetrahydrofuran; water / 20 °C

With sodium hydride; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2021.128266