Ethyl 2-(2,6-difluorophenyl)acetate

Base Information

Chemical Name:Ethyl 2-(2,6-difluorophenyl)acetate
CAS No.:680217-71-4
Molecular Formula:C10H10F2O2
Molecular Weight:200.185
Hs Code.:2916399090
DSSTox Substance ID:DTXSID40381906
Wikidata:Q82173089
Mol file:680217-71-4.mol

Synonyms:ethyl 2-(2,6-difluorophenyl)acetate;680217-71-4;Ethyl (2,6-Difluorophenyl)acetate;Ethyl 2,6-difluorophenylacetate;Benzeneacetic acid, 2,6-difluoro-, ethyl ester;SCHEMBL1867904;DTXSID40381906;Ethyl(2,6-difluorophenyl)acetate;ethyl2-(2,6-difluorophenyl)acetate;MFCD01765417;AKOS009159530;PS-6528;(2,6-Difluorophenyl)acetic acid ethyl ester;A867142

Suppliers and Price of Ethyl 2-(2,6-difluorophenyl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Ethyl 2-(2,6-difluorophenyl)acetate
250 mg
$ 128.00

SynQuest Laboratories
Ethyl 2-(2,6-difluorophenyl)acetate
1 g
$ 256.00

Rieke Metals
(2,6-Difluorophenyl)aceticacidethylester
1g
$ 527.00

Matrix Scientific
Ethyl (2,6-difluorophenyl)acetate 97%
1g
$ 488.00

Labseeker
Benzeneaceticacid,2,6-difluoro-,ethylester 95
100g
$ 1100.00

Crysdot
Ethyl2-(2,6-difluorophenyl)acetate 95+%
10g
$ 301.00

Chemenu
Ethyl(2,6-difluorophenyl)acetate 95%
5g
$ 196.00

Chemenu
Ethyl(2,6-difluorophenyl)acetate 95%
10g
$ 284.00

Atlantic Research Chemicals
Ethyl(2,6-Difluorophenyl)acetate 95%
1gm:
$ 187.33

Apolloscientific
Ethyl2,6-difluorophenylacetate
250mg
$ 116.00

Total 9 raw suppliers

Chemical Property of Ethyl 2-(2,6-difluorophenyl)acetate

Chemical Property:

Boiling Point:221.9±25.0 °C(Predicted)
PSA：26.30000
Density:1 +-.0.06 g/cm3(Predicted)
LogP:2.07040
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:200.06488588
Heavy Atom Count:14
Complexity:187

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 2-(2,6-difluorophenyl)acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1=C(C=CC=C1F)F
Uses Ethyl 2-(2,6-Difluorophenyl)acetate is a useful reactant for the preparation of mono α-?aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-?1-?imidazole carbamate.

Technology Process of Ethyl 2-(2,6-difluorophenyl)acetate

There total 4 articles about Ethyl 2-(2,6-difluorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: potassium (2,6-difluorobenzyl)trifluoroborate

: 2-(ethoxycarbonyl)-1,3-dimethyl-1H-imidazole-3-ium trifluoromethanesulfonate

: 680217-71-4
(2,6-difluorophenyl)acetic acid ethyl ester

Guidance literature:: With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In dichloromethane; for 18h; Irradiation; Inert atmosphere; Glovebox; Sealed tube;
DOI:10.1016/j.tet.2021.132288

Reference yield:

: 64-17-5
ethanol

: 85068-28-6
2,6-difluorophenylacetic acid

: 680217-71-4
(2,6-difluorophenyl)acetic acid ethyl ester

Guidance literature:: With sulfuric acid; for 14h; Reflux;
DOI:10.1021/jm200385u

Reference yield:

: 85118-00-9
2,6-Difluorobenzyl bromide

: 680217-71-4
(2,6-difluorophenyl)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; copper(l) iodide; lithium methanolate / N,N-dimethyl-formamide / 24 h / Inert atmosphere; Glovebox; Sealed tube

2: methanol; water / 0 - 20 °C

3: [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate / dichloromethane / 18 h / Irradiation; Inert atmosphere; Glovebox; Sealed tube

With copper(l) iodide; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; lithium methanolate; triphenylphosphine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2021.132288