(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine

Base Information

• Chemical Name: (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine
• CAS No.: 314771-76-1
• Molecular Formula: C18H16ClFN4O2
• Molecular Weight: 374.7966432
• Hs Code.: 2934999090
• Mol file: 314771-76-1.mol

Synonyms: (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine;N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine;7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl) aMino-6-aMinoquinazoline;Afatinib IMpurity B;Afatinib intermediate D;N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl];Afatinib INT;4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-amine-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

Chemical Property of (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine

Chemical Property:

• Boiling Point: 559.0±50.0 °C(Predicted)
• PKA: 5.89±0.30(Predicted)
• PSA: 82.29000
• Density: 1.473±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 4.57000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl(Contained~8.5%Ethanol) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine

There total 32 articles about (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline (314771-88-5,402855-07-6) → 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline (314771-76-1,402855-03-2)

Guidance literature:

With hydrogen; ammonium chloride; nickel; In N,N-dimethyl-formamide; at 40 ℃;

Reference yield: 97.0%

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(R)-(tetrahydrofuran-3-yl)oxy]quinazoline (314771-88-5,402855-07-6) → 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline (314771-76-1,402855-03-2)

Guidance literature:

With hydrazine hydrate; In ethanol; at 75 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.catcom.2022.106398

Reference yield: 90.0%

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-(5-tetrahydrofuran-3-yloxy)quinazoline (314771-88-5,402855-07-6) → N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy) quinazoline-4,6-diamine (314771-76-1,402855-03-2)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazoline

3-chloro-4-fluorophenylamine

4-chloro-7-fluoro-6-nitroquinazoline

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

Refernces

• 1、 Fu, Lihua,Li, Dingzhong,Lu, Hao,Qiu, Renhua,Sun, Tulai,Xing, Chen,Yang, Tianbao. "Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes". . . Retrieved 2022/01/11.
• 2、 -. "Synthetic method of afatinib intermediate". Paragraph 0020-0021. . Retrieved 2020/07/15.