(E)-methyl-4-(4-bromophenyl)-2-oxobut-3-enoate

Base Information

• Chemical Name: (E)-methyl-4-(4-bromophenyl)-2-oxobut-3-enoate
• CAS No.: 608128-34-3
• Molecular Formula: C₁₁H₉BrO₃
• Molecular Weight: 269.095
• Hs Code.: 2918300090
• Mol file: 608128-34-3.mol

Synonyms:(E)-methyl-4-(4-bromophenyl)-2-oxobut-3-enoate;Methyl (3E)-4-(4-bromophenyl)-2-oxobut-3-enoate

Chemical Property of (E)-methyl-4-(4-bromophenyl)-2-oxobut-3-enoate

Chemical Property:

• Melting Point: 120 °C(Solv: methanol (67-56-1))
• Boiling Point: 359.8±34.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.493±0.06 g/cm3(Predicted)
• LogP: 2.20440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(E)-Methyl4-(4-Bromophenyl)-2-oxobut-3-enoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (E)-Methyl 4-(4-bromophenyl)-2-oxobut-3-enoate is a useful reactant for the synthesis of oxygenated and aminated chromans.

Technology Process of (E)-methyl-4-(4-bromophenyl)-2-oxobut-3-enoate

There total 8 articles about (E)-methyl-4-(4-bromophenyl)-2-oxobut-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

methanol (67-56-1) + potassium (E)-4-(4-bromophenyl)-2-oxobut-3-enoate → methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate (104093-34-7,608128-34-3)

Guidance literature:

methanol; With acetyl chloride; at 0 ℃;

potassium (E)-4-(4-bromophenyl)-2-oxobut-3-enoate; at 20 - 25 ℃; for 8h; Reflux;

DOI:10.1016/j.tetasy.2017.01.002

Reference yield: 35.0%

methanol (67-56-1) + 2-oxo-propionic acid (127-17-3) + 4-bromo-benzaldehyde (1122-91-4) → methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate (104093-34-7,608128-34-3)

Guidance literature:

2-oxo-propionic acid; 4-bromo-benzaldehyde; With potassium hydroxide;

methanol; Further stages.;

DOI:10.1002/chem.200700995

Reference yield:

methanol (67-56-1) + 4-bromo-(3-carboxyl-3-oxoprop-1-enyl)benzene (139005-22-4) → methyl (E)-2-oxo-4-(4-bromophenyl)-3-butenoate (104093-34-7,608128-34-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1007/BF03344016

upstream raw materials:

methanol

4-bromo-(3-carboxyl-3-oxoprop-1-enyl)benzene

4-bromo-benzaldehyde

2-oxo-propionic acid

Downstream raw materials:

trimethyl (S,Z)-2-(4-bromophenyl)-4-(cinnamoyloxy)but-3-ene-1,1,4-tricarboxylate