4,6-dichloro-1-Methyl-1H-iMidazo[4,5-c]pyridine

Base Information

• Chemical Name: 4,6-dichloro-1-Methyl-1H-iMidazo[4,5-c]pyridine
• CAS No.: 887147-19-5
• Molecular Formula: C7H5Cl2N3
• Molecular Weight: 202.043
• Hs Code.: 2933990090
• Mol file: 887147-19-5.mol

Synonyms:4,6-dichloro-1-Methyl-1H-iMidazo[4,5-c]pyridine

Chemical Property of 4,6-dichloro-1-Methyl-1H-iMidazo[4,5-c]pyridine

Chemical Property:

• Boiling Point: 367.5±52.0 °C(Predicted)
• PKA: 1.86±0.30(Predicted)
• PSA: 30.71000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 2.27510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4,6-Dichloro-1-methyl-1H-imidazo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-dichloro-1-Methyl-1H-iMidazo[4,5-c]pyridine

There total 15 articles about 4,6-dichloro-1-Methyl-1H-iMidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-amino-4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridine (805316-72-7) → 4,6-dichloro-1-methyl-1H-imidazo [4,5-c]pyridine (887147-19-5)

Guidance literature:

7-amino-4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridine; With sodium nitrite;

With hypophosphorous acid; at 100 ℃;

DOI:10.1016/j.bmcl.2009.03.159

Reference yield: 97.0%

trimethyl orthoformate (149-73-5) → 4,6-dichloro-1-methyl-1H-imidazo [4,5-c]pyridine (887147-19-5)

Guidance literature:

2,6-dichloro-N-methyl-3-nitro pyridine-4-amine; With hydrogenchloride; tin(ll) chloride; In methanol; water; for 1h; Heating / reflux;

trimethyl orthoformate; In methanol; for 1h; Product distribution / selectivity; Heating / reflux;

Reference yield: 88.9%

2,6-dichloro-4-N-methylpyridine-3,4-diamine (914942-86-2) + orthoformic acid triethyl ester (122-51-0) → 4,6-dichloro-1-methyl-1H-imidazo [4,5-c]pyridine (887147-19-5)

Guidance literature:

In ethanol; at 105 ℃; for 36h;

DOI:10.1039/c6nj02069k

upstream raw materials:

7-amino-4,6-dichloro-1-methyl-1H-imidazo[4,5-c]pyridine

trimethyl orthoformate

2,6-dichloro-4-N-methylpyridine-3,4-diamine

orthoformic acid triethyl ester

Refernces

• 1、 -. "ALKYNYL ALCOHOLS AND METHODS OF USE". Paragraph 0557; 0558. . Retrieved 2015/03/04.
• 2、 Kempson, James,Guo, Junqing,Das, Jagabandhu,Moquin, Robert V.,Spergel, Steven H.,Watterson, Scott H.,Langevine, Charles M.,Dyckman, Alaric J.,Pattoli, Mark,Burke, James R.,Yang, XiaoXia,Gillooly, Kathleen M.,McIntyre, Kim W.,Chen, Laishun,Dodd, John H.,McKinnon, Murray,Barrish, Joel C.,Pitts, William J.. "Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IκB kinase". scheme or table. p. 2646 - 2649. Retrieved 2009/12/31.