914942-86-2

Basic information

• Product Name: 2,6 - Dichloro - N4 - Methylpyridine - 3,4 - diaMine
• Synonyms: 2,6 - Dichloro - N4 - Methylpyridine - 3,4 - diaMine
• CAS NO: 914942-86-2
• Molecular Formula: C6H7Cl2N3
• Molecular Weight: 192.04588
• Mol File: 914942-86-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6 - Dichloro - N4 - Methylpyridine - 3,4 - diaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6 - Dichloro - N4 - Methylpyridine - 3,4 - diaMine(914942-86-2)
• EPA Substance Registry System: 2,6 - Dichloro - N4 - Methylpyridine - 3,4 - diaMine(914942-86-2)

Safety Data

• Hazardous Substances Data: 914942-86-2(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-N4-methylpyridine-3,4-diamine is a chemical compound that consists of a pyridine ring with a methyl group and two chlorine atoms attached at the 2 and 6 positions. Additionally, it contains two amino groups at the 3 and 4 positions of the pyridine ring. 2,6 - Dichloro - N4 - Methylpyridine - 3,4 - diaMine is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its ability to act as a building block for the creation of diverse chemical structures. It is also known for its strong odor and is classified as a dangerous substance, requiring proper handling and disposal procedures. Overall, the chemical has applications in various industries and plays a crucial role in the production of important compounds.

Upstream product

• 914942-85-1 2,6-dichloro-N-methyl-N-nitro pyridine-4-amine 
• 2587-00-0 2,6-dichloropyridine N-oxide 
• 2402-78-0 2,6-dichloropyridine 
• 1569084-56-5 tert-butyl 2,6-dichloropyridin-4-yl(methyl)carbamate 
• 501907-61-5 tert-butyl (2,6-dichloropyridin-4-yl)carbamate 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 175461-33-3 2,6-dichloro-N-methylpyridine-4-amine 
• 16063-69-7 2,4,6-trichloropyridine 
• 887147-20-8 2,6-dichloro-N-methyl-3-nitro pyridine-4-amine 

Downstream Products

• 887147-19-5 4,6-dichloro-1-methyl-1H-imidazo [4,5-c]pyridine 
• 914944-26-6 3-((4-tert-butyloxycarbonyl(methyl)amino)-1-methyl-6-(2,2,2-trifluoroacetamido)-1H-imidazo[4,5-c]pyridin-7-yl)ethynyl-5-fluorobenzoic acid methyl ester 
• 914943-46-7 N-[[3-[1,5-dihydro-1-methyl-4-(methyl-t-butyloxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]phenyl]methyl]trimethylacetamide 
• 914943-90-1 3-[6-amino-4-(tert-butoxycarbonyl-methyl-amino)-1-methyl-1H-imidazo[4,5-d]pyridin-7-ylethynyl]-benzoic acid tert-butyl ester 
• 914944-25-5 3-((6-amino-4-(tert-butyloxycarbonyl(methyl)amino)-1-methyl-1H-imidazo[4,5-c]pyridine-7-yl)ethynyl)-5-fluorobenzoic acid methyl ester 
• 914944-30-2 3-[1,6-dihydro-1-methyl-4-((methyl)tert-butoxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]-5-fluoro-benzoic acid 
• 914942-98-6 N-[[3-[1,6-dihydro-1-methyl-4-(methyl-t-butyloxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]phenyl]methyl]acetamide 
• 914944-27-7 3-[1,6-dihydro-1-methyl-4-((methyl)tert-butoxycarbonylamino)imidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]-5-fluoro-benzoic acid methyl ester 

Relevant articles and documents

Synthesis and evaluation of novel imidazo[4,5-: C] pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacological activities were determined by the objective to better understand their structure-activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened, compounds 21, 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model, 21, 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg-1 body weight.

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY

The present invention provides for tricyclic compounds having the formula (I) wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.