2-(2-Cyano-vinylaMino)-Malonicaciddiethylester

Base Information

• Chemical Name: 2-(2-Cyano-vinylaMino)-Malonicaciddiethylester
• CAS No.: 1021175-71-2
• Molecular Formula: C10H14N2O4
• Molecular Weight: 226.23
• Mol file: 1021175-71-2.mol

Synonyms:2-(2-Cyano-vinylaMino)-Malonicaciddiethylester;(E)-Diethyl 2-((2-cyanovinyl)aMino)Malonate

Chemical Property of 2-(2-Cyano-vinylaMino)-Malonicaciddiethylester

Chemical Property:

• PSA: 88.42000
• LogP: 0.49898

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Cyano-vinylamino)malonicAcidDiethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Cyano-vinylaMino)-Malonicaciddiethylester

There total 5 articles about 2-(2-Cyano-vinylaMino)-Malonicaciddiethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

aminomalonic acid diethyl ester (6829-40-9) + 3-hydroxyacrylonitrile sodium salt (76064-23-8) → diethyl 2-(2-cyanovinylamino)malonate (1021175-71-2)

Guidance literature:

With sodium acetate; acetic acid; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2014.05.046

Reference yield: 37.0%

ISOXAZOLE (288-14-2) + diethyl aminomalonate hydrochloride (13433-00-6) → diethyl 2-(2-cyanovinylamino)malonate (1021175-71-2)

Guidance literature:

ISOXAZOLE; With sodium ethanolate; In ethanol; at 0 ℃; for 0.5h;

diethyl aminomalonate hydrochloride; sodium acetate; acetic acid; In ethanol; at 20 ℃; for 48h;

Reference yield:

3-dimethylaminoacrylonitrile (2407-68-3) + diethyl aminomalonate hydrochloride (13433-00-6) → diethyl 2-(2-cyanovinylamino)malonate (1021175-71-2)

Guidance literature:

With acetic acid; In dichloromethane; Solvent; Reagent/catalyst;

upstream raw materials:

cyanoacetaldehyde

diethyl aminomalonate hydrochloride

aminomalonic acid diethyl ester

ISOXAZOLE

Downstream raw materials:

3-amino-2-ethoxycarbonylpyrrole

9-deazahypoxanthine

ethyl 3-(6-methoxy-7-(3-(4-phenylpiperazin-1-yl)propoxy)quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate

ethyl 3-(7-methoxy-6-(3-(4-phenylpiperazin-1-yl)propoxy)quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate

Refernces

• 1、 Dimitrakis, Spyridon,Gavriil, Efthymios-Spyridon,Gioti, Katerina,Lougiakis, Nikolaos,Marakos, Panagiotis,Pouli, Nicole,Pousias, Athanasios,Tenta, Roxane. "Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation". . . Retrieved 2022/01/06.
• 2、 Malcor, Jean-Daniel,Brouillette, Yann,Graffion, Julien,Spielmann, Kim,Masurier, Nicolas,Maillard, Ludovic T.,Martinez, Jean,Lisowski, Vincent. "Synthesis and reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione. Access to new pyrrolo[3,2-e][1,4]diazepine-2,5-diones". . p. 4631 - 4639. Retrieved 2014/06/23.