76064-23-8

Basic information

• Product Name: Sodium 3-cyanoprop-1-enoxide
• CAS NO: 76064-23-8
• Molecular Weight: 91.0448
• Mol File: 76064-23-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Sodium 3-cyanoprop-1-enoxide(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium 3-cyanoprop-1-enoxide(76064-23-8)
• EPA Substance Registry System: Sodium 3-cyanoprop-1-enoxide(76064-23-8)

Safety Data

• Hazardous Substances Data: 76064-23-8(Hazardous Substances Data)

Usage

General Description

Sodium 3-cyanoprop-1-enoxide is a chemical compound with the molecular formula C3H3NNaO. It is a derivative of propenoic acid, containing a cyanide group at the third carbon position and a sodium ion. Sodium 3-cyanoprop-1-enoxide is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-carbon bonds. It is also utilized in the production of pharmaceuticals, agrochemicals, and dyes. When handled and used properly, sodium 3-cyanoprop-1-enoxide can be an important tool in chemical research and manufacturing processes.

Upstream product

• 124-38-9 carbon dioxide 
• 7440-44-0 pyrographite 
• 75-05-8 acetonitrile 
• 124-41-4 sodium methylate 
• 109-94-4 formic acid ethyl ester 
• 288-14-2 ISOXAZOLE 

Downstream Products

• 1021175-71-2 diethyl 2-(2-cyanovinylamino)malonate 
• 71-30-7 Cytosine 
• 61310-53-0 3-ethoxyacrylonitrile 
• 2032-34-0 3,3-bis(ethyloxy)propanenitrile 
• 60722-70-5 2-benzylsulfanyl-pyrimidin-4-ylamine 
• 54308-63-3 2-ethylsulfanyl-pyrimidin-4-ylamine 
• 2183-66-6 4-amino-2-(methylthio)pyrimidine 
• 3289-47-2 4-amino-2-methoxypyrimidine 
• 333-49-3 2-thiocytosine 

Relevant articles and documents

3 - Ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of synthetic method

The invention belongs to the field of medicinal chemistry, in particular to medicinal chemistry of the in the field of organic synthesis, more in particular to 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of synthetic method. The method uses acetonitrile with a ester alcohol under the action of the alkali metal salt, to obtain the intermediate compound II, then this compound II and then under the action of the phase transfer catalyst, with the sulfuric acid b b obtained by the target mixture compound I, namely 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture. The invention disclosed 3 - ethoxy acrylonitrile and 3, 3 - diethyl dimethoxypropionitrile is treated mixture of the synthetic method has low material cost, relatively mild reaction conditions, the operation is simple, the yield and the like, which is suitable for the industrial production, application of the method.

Synthesis and reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione. Access to new pyrrolo[3,2-e][1,4]diazepine-2,5-diones

A convenient synthesis of pyrrolo[3,2-d][1,3]oxazine-2,4-dione 4 is described and its reactivity towards various nucleophiles studied. The regioselective ring opening of anhydride 4 or its N-alkylated analog 25 in the presence of alanine or proline afforded, respectively, imidazolidinedione 22 and N-protected pyrrolo[3,2-e][1,4]diazepines 30 and 31 in a one-pot process. In a last part of this study, an alternative route to produce a library of eight non protected pyrrolo[3,2-e][1,4]diazepine-2,5-diones 35a-h is described to overcome the limited reactivity of anhydride 4.