Chemical Property of Octanoic acid, 6,8-bis[(phenylMethyl)thio]-
Chemical Property:
- Melting Point:63-65℃
- Boiling Point:553.0±50.0 °C(Predicted)
- PKA:4.75±0.10(Predicted)
- PSA：87.90000
- Density:1.149
- LogP:6.25690
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble15mg/mL (clear solution)
- Purity/Quality:
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99%, *data from raw suppliers
CPI613 *data from reagent suppliers
Safty Information:
- Pictogram(s):
N
- Hazard Codes:N
- Statements:
50/53
- Safety Statements:
60-61
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
CPI-613 (95809-78-2) is a lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1?? Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic properties.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5
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Uses
CPI 613 is a class of non-redox-active lipoate derivative that disrupts cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. 6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cellsto induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysatesto validate basal respiration in tissue respirometry
